ID A0A0N4TN95_BRUPA Unreviewed; 509 AA.
AC A0A0N4TN95;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE SubName: Full=PAP2_C domain-containing protein {ECO:0000313|WBParaSite:BPAG_0000995101-mRNA-1};
GN ORFNames=BPAG_LOCUS9913 {ECO:0000313|EMBL:VDN91099.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0000995101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0000995101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN91099.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR EMBL; UZAD01013169; VDN91099.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4TN95; -.
DR STRING; 6280.A0A0N4TN95; -.
DR WBParaSite; BPAG_0000995101-mRNA-1; BPAG_0000995101-mRNA-1; BPAG_0000995101.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01610; PAP2_like; 1.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF27; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 239..311
FT /note="Sphingomyelin synthase-like"
FT /evidence="ECO:0000259|Pfam:PF14360"
SQ SEQUENCE 509 AA; 57721 MW; 9E88A4082FBD3206 CRC64;
MKENEVWLPK RVTTRKVMLD GQITTASSAT RRICSSSNSE DHSEDNYDDE GRAPLLNGLL
SSANNAVKID LNSSIIVQTS KNSFDKFPKE RCKAAKLKIS VGLLITAAVC NDLVLSFIHE
KVPQEPPLPD AVFAHTPYIP WALTVSEYLM LASFTCMLAL TVLHRHRWII LRRIAVIGSL
LYFGRCLTML VTQVPIADPN YYCSPRLSGA DYTLRNIFLR AMRIVSGAGL MINGKHTLCG
DYIYSGHTVV LVTSCLFITE YSPQRWKPLH FFSIMVSAAG VILLLISRAH YTIDVIISYW
ISTRVFWTYH TLAAFPNLRN ASSHYNHLSK FYWYRLFLFM EGNLHRPVPR SCGFKSHFHL
IWVLFKNKNF GQIIFSKMIS KGLIGRFLGC ALVRGLLAKQ TYRKKNDSFW TTKISIKQQV
TYNCKELYLC AGIDRREKCS TQKLILVNGI LNYCFGNLEL SKLYLSKINL REGFPLQSSS
VTAGVAAASE LLKNLAFLLY QKLICAIND
//
