ID A0A0N4TQ86_BRUPA Unreviewed; 1179 AA.
AC A0A0N4TQ86;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Peptidase M12B domain-containing protein {ECO:0000313|WBParaSite:BPAG_0001074601-mRNA-1};
GN ORFNames=BPAG_LOCUS10708 {ECO:0000313|EMBL:VDN91894.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001074601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001074601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN91894.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR EMBL; UZAD01013197; VDN91894.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4TQ86; -.
DR STRING; 6280.A0A0N4TQ86; -.
DR WBParaSite; BPAG_0001074601-mRNA-1; BPAG_0001074601-mRNA-1; BPAG_0001074601.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF13582; Reprolysin_3; 1.
DR Pfam; PF00090; TSP_1; 5.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT DOMAIN 223..419
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT ACT_SITE 374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 373
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 377
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 383
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 1179 AA; 130410 MW; 0CADE5957376B94B CRC64;
MAYSMQWIFQ YSLTESTTAP FLSSEELRYT FGVHTFPDVP QYEELYPEAE YSEDGQLKLL
HITIHGKQVN FTLQPTIQSL VSPHLKTVFR NAHGGGKLEV GLPPISCHYQ HKSKDVYAAI
SNCDGNLVIK NENTDAGKKG IIVVTDDVYV LHPLPDRHAH RFDQNNRNGS DPGLHVIYKR
EATRKEFCGL ESTITSTELA EGENEVSEDV FAVGQRLNEE GELIVELAIF VDEMLWKLFS
SKYGVDAATK LRDYALTMLN NVQIMYHQPS AIPQLSFHVV RFEVLTIQPS AMADHLHNSG
HAQKYLDRFC KYQRSLSTRD WDHALLLTGY DIHRGTGSRS ISGIARLDGM CDPWNSCTLA
EGLDFTSAFI GTHELGHSVG MRHDEPYCPA KHIMSSSLGP GKVTWSICSL RDYHVFLQRL
DSRDKNCLRV SNLPQKLTMR TDLKPGQVYN ADMQCYIMHG QGYRQVISPR QDHYDGICYM
IWCGQSSFGR IITSHPALEG TFCGSSKWCE LGRCVPWPGV DPTAIPKRID GQWSEWSAIS
CQSCNCADIA GSIGISTSTR RCSNPSPANG GAECVGATLR AIICNRLCTS SSKSVDKSKS
NADLLLLQHI KEHCTQQKRL KSDSDLTGSG TQLIRYPQRA CKVFCDVISR YGSQRNYRFF
GDILPDGAPC GTNKYCLDGE CLPLSCDNNA LITRDLSCPI ASEWCRQENE ITNAVSTSAG
ARWSSWSTWS SCSHTCGIGY RQRSSSKLNV LAISDEGYRT RSCSNTKNQC SGVSSEKTQC
NLSACGTNTV SDQKSSWSEW TSWNQCSVSC DIGSQARYRR CFSSHNSLSF SCPENSMETR
QCNMGECNTG TVGLWGSWTE WSQCSVSCGP GIRNRNRYCT KEPCDGSGQS RMSCNLGPCE
ISIRWLQWEA WSQCSLTCGK GVRTRKRKCS ATNGCFGSSL EQLNCNENLC TVAGTTTVGQ
WSGWSDWSTC STTCGGGFKR RTRLCQRGTC NGPSKDSLPC MIKHCKSFSS GTTASWGGKY
SSTGAITLAE ISYGSSLVTT EPSVRTASGT NYSFSSIGLT DVSFAKRNLR RFWLFSNGSL
SRTAEPDPVG VIGHRVLKHA VEVSGSGYAN AMAKVGSVLE MNMSEKYATC DDAEDKLVHV
LVASKYCEHV TCLVSCACAF FEFLLNLKCQ LQLGTNLVY
//
