ID A0A0N4TQM1_BRUPA Unreviewed; 1654 AA.
AC A0A0N4TQM1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BPAG_LOCUS10862 {ECO:0000313|EMBL:VDN92048.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001090001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001090001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN92048.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; UZAD01013202; VDN92048.1; -; Genomic_DNA.
DR STRING; 6280.A0A0N4TQM1; -.
DR WBParaSite; BPAG_0001090001-mRNA-1; BPAG_0001090001-mRNA-1; BPAG_0001090001.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity; IEA:InterPro.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:InterPro.
DR Gene3D; 3.40.50.800; Anticodon-binding domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR016255; Gcn2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR11042:SF197; EIF-2-ALPHA KINASE GCN2; 1.
DR PANTHER; PTHR11042; EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF05773; RWD; 1.
DR PIRSF; PIRSF000660; Ser/Thr_PK_GCN2; 3.
DR SMART; SM00591; RWD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50908; RWD; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000660-
KW 2}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000660-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 32..147
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT DOMAIN 559..967
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 730..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 817
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000660-1"
FT BINDING 565..573
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000660-2"
FT BINDING 588
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000660-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1654 AA; 187559 MW; E4476B57F6282C73 CRC64;
MKSMEHRQYE QRSAAVGDIG GTLDDAKRRQ RDERIVLESV YGEDFRDAAQ NAWKIWQPLD
VILHLKPVRS VSTTSGKIYV SLDLHVKCPK TYPLYGIPLI ALENIQGISL RDIDKLKQML
DNKAASLKGN EIVLELCQVV QEFLYERNKP PEGSFFDGML QQHAAVEHER RRQRVRSEQR
DREDVVAFQK MHEEKLMWRK AEEGEPTTPV DDSSYETFSC IDGVQRRLTK MNDFRRRPNI
SPFCREWSAV DYATGHELFI TEWTFAATAK TPISSLKPFI THFKQLEKKL KQISRISVTE
PTLCSYEMLC VQKNKLTVSE INVWQALLHI TFSDSGNISC GSHRMICINT VVSFKLQVNC
SVIIGQNIDG NDRNLSSQID IFETDKTLLV RLAVQLLDGL RFLHERNLGH FDLDLMSIWI
TGKRNFRLSD YFLRSLILDR YRIIKECIEM VGENIASGSS IDKLPHNDLA SLGNIFSKFR
GLPAVANDPD FSKNLESFVK ACRNTKILKI LMEHPFLHQG ICSEEEVVRL FSDDLFQSLI
DVEKEGFQQI AHSRLRNEFI FIEMLGKGGF GDVMLAKNKL DGNDYAIKRI PLDPKDERFS
RKVTREAKLF SKLNHPNVVR YYSAWIEQAS TVTREAGPES SSSEVNVNSG QKVGTEDSLV
PMQIKNNEKV AKRLAVDTTA EWSTSFQVAS MYELDSVSEE QCKEPVRTLF SPTGLSTVEN
SDFEVLFEDE GDNEDSSDEN VDTPSNRTLP SGTTARNSST LSLRILFIQM EYCEKSTLRN
LIDSSKLLKN PRQIWRLFRE ILLGLQYIHQ EGMIHRDIKP MNVLIDGSDH AKIGDFGLAT
RDIMSKNLSS LNESDMNFSM TKDIGTALYI APELLSTAGE SIDYTTKIDV YSLGIVLFEM
FYRPLLPGME RIAVIKNLRG SGHFPSDFGT GMLEIHQKAA KKLIKWMLEI QPDDRPSVQI
LLESDRIPVA EIEENDFQKM FCQAIRSRGR LHHWIIDTLI ANPVLPAADY LYDRGICSAD
RLSLPRLRAV ESLRNRLCRI CSTHAFIPLD MHSITPFNAK NAPEMTNSKS RACRFVDENG
ISVMLPYDLR RAFARYCVRN GVNRLKRYDC GKVFGRPDAA GKTSTFLNIM CSSVYEQIFA
GSEMYYVSIV SMHPIERIEF AIDAVGPISS SQMLTADILC ITVETVHQLD CISSHKWEIR
IGHRDLIIAA ILYLGFGDFS TQNKILNILY AIATSNKMLN REQKIERLRA GTEMSFSQAN
SLLNVLEGDD CTLEALVART ECLVNCRDDR VQKHSKKALS DLTNLAILLK CFIDDMTEHI
LFDGTLCYRP HTYCSGLMFQ LRVLVLHKQT IRPVIIGAGG RYDTLLDDER HAQDLIPPTP
LCAVGCSLSL DILAHFCCTN KPDFGSVCGQ ALVCSVSDQF LKTTANLVKQ MWSCGIQTDV
LHDPVAPMQI TELIEHCNET HIEMLLVVYG EDEVLTRIGG VDLGKLTFDE MLSKFEVYQN
DVSFVEAFPH LSNITSTVRH SLNTLPVAAT PASLNVRYAL TEKPAAHVRK RNETQIRACL
QKVVIALAPQ TVVEVVVTEI SVDAIRLLAT LIDRNFTVDE LLSAFTAAAK QLSKFKREFK
RIEEVIEPFF QLKNTSPIVL YSKQDCNGYY KLIL
//
