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Database: UniProt
Entry: A0A0N4TQM7_BRUPA
LinkDB: A0A0N4TQM7_BRUPA
Original site: A0A0N4TQM7_BRUPA 
ID   A0A0N4TQM7_BRUPA        Unreviewed;       485 AA.
AC   A0A0N4TQM7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   ORFNames=BPAG_LOCUS10869 {ECO:0000313|EMBL:VDN92055.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001090701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001090701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN92055.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
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DR   EMBL; UZAD01013203; VDN92055.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4TQM7; -.
DR   STRING; 6280.A0A0N4TQM7; -.
DR   WBParaSite; BPAG_0001090701-mRNA-1; BPAG_0001090701-mRNA-1; BPAG_0001090701.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR22883:SF414; PALMITOYLTRANSFERASE ZDHHC24-RELATED; 1.
DR   PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        71..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        157..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        218..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          110..249
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
SQ   SEQUENCE   485 AA;  56465 MW;  66003173DA2E0E4B CRC64;
     MQYKQNRLHC DGVINHMDMF EDFTGRLREI LPSETQDRIA MFILFILLPL GFLFEIFAIL
     PTEHEVMSKG WNLRVGILML FGLNAFANVY KVISVGPNGN CSDLPAVQKH GYRFCYNCQL
     NEPPRSHHCP VCDRCVFRRD HHSSFVAVCV GHFNQRYYIS AICSLWIISL TVLMWNWSFM
     WTSLGGFSPL QLWELIVPHL ALIFRIISFS QFLCVMTFIF SFTVFVFLCY LITAQLFCLY
     RGQTRVEYLM DVHAYNLGFM ENVRQAMGRR WFIALLMPFI SSPLDSDGLS YPTRESKPLN
     DMKTIFGFCL YRNSPSLVDL RMCTNLITAT NEVINRELLI IIAVSRIILK RNVLLVTVGT
     SLNLKINDKH RSKRGMNQSS LSLEDVDYRF NKCLRKAMND MRQLVKGEIS EDELDVEQGF
     QQLAVGTMIE NFTKILLDNE KVDYADVNVE MRLKDIRYNS RKQNNHFFSY RSKGLDERGG
     RIMRN
//
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