ID A0A0N4TQM7_BRUPA Unreviewed; 485 AA.
AC A0A0N4TQM7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN ORFNames=BPAG_LOCUS10869 {ECO:0000313|EMBL:VDN92055.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001090701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001090701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN92055.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR EMBL; UZAD01013203; VDN92055.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4TQM7; -.
DR STRING; 6280.A0A0N4TQM7; -.
DR WBParaSite; BPAG_0001090701-mRNA-1; BPAG_0001090701-mRNA-1; BPAG_0001090701.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR22883:SF414; PALMITOYLTRANSFERASE ZDHHC24-RELATED; 1.
DR PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU079119}; Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 71..90
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 157..180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 110..249
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
SQ SEQUENCE 485 AA; 56465 MW; 66003173DA2E0E4B CRC64;
MQYKQNRLHC DGVINHMDMF EDFTGRLREI LPSETQDRIA MFILFILLPL GFLFEIFAIL
PTEHEVMSKG WNLRVGILML FGLNAFANVY KVISVGPNGN CSDLPAVQKH GYRFCYNCQL
NEPPRSHHCP VCDRCVFRRD HHSSFVAVCV GHFNQRYYIS AICSLWIISL TVLMWNWSFM
WTSLGGFSPL QLWELIVPHL ALIFRIISFS QFLCVMTFIF SFTVFVFLCY LITAQLFCLY
RGQTRVEYLM DVHAYNLGFM ENVRQAMGRR WFIALLMPFI SSPLDSDGLS YPTRESKPLN
DMKTIFGFCL YRNSPSLVDL RMCTNLITAT NEVINRELLI IIAVSRIILK RNVLLVTVGT
SLNLKINDKH RSKRGMNQSS LSLEDVDYRF NKCLRKAMND MRQLVKGEIS EDELDVEQGF
QQLAVGTMIE NFTKILLDNE KVDYADVNVE MRLKDIRYNS RKQNNHFFSY RSKGLDERGG
RIMRN
//