ID A0A0N4TRM5_BRUPA Unreviewed; 751 AA.
AC A0A0N4TRM5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Proton-coupled zinc antiporter SLC30A5 {ECO:0000256|ARBA:ARBA00040846};
DE AltName: Full=Solute carrier family 30 member 5 {ECO:0000256|ARBA:ARBA00042217};
DE AltName: Full=Zinc transporter 5 {ECO:0000256|ARBA:ARBA00042038};
GN ORFNames=BPAG_LOCUS11269 {ECO:0000313|EMBL:VDN92455.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001130701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001130701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN92455.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out);
CC Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00034428};
CC -!- SUBUNIT: Heterodimer with SLC30A6/ZNT6; form a functional zinc ion
CC transmembrane transporter. {ECO:0000256|ARBA:ARBA00038531}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Cytoplasmic vesicle, secretory vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004638}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004638}. Golgi apparatus, Golgi stack membrane
CC {ECO:0000256|ARBA:ARBA00004205}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004205}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily.
CC {ECO:0000256|ARBA:ARBA00008873}.
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DR EMBL; UZAD01013222; VDN92455.1; -; Genomic_DNA.
DR STRING; 6280.A0A0N4TRM5; -.
DR WBParaSite; BPAG_0001130701-mRNA-1; BPAG_0001130701-mRNA-1; BPAG_0001130701.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:InterPro.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR45755; -; 1.
DR PANTHER; PTHR45755:SF1; ZINC TRANSPORTER 5; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 22..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 533..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 751 AA; 83828 MW; 84921956A00DEC4F CRC64;
MLAQDFLRKD DRSFLPTSSS KSALYFGLLV IVKFLRCIGI FIIDILAKQV HVVGLLWFFK
LVASCILIPF QKPFNHGKSL KRVLGIKIVQ LALWNCLIEV IWFYGITFCG PLRSILVFEQ
SPSVIMVALL TLLKGSNSSS KTRGVIALML GYLSLILMDS DATVESNHKS SHSHQSVLNH
LFYHFIHNSG VSDHKGGVIL LIFAVLIKMA YDSSFRHLAV EIGGPKRLYS LVTLFSAIFL
TPVAILAFAM GEVYITSFID FILLLFMGSM FVMVFDFYTE SFCFQHVADP VLSSARWSPM
IMFVCAFMFA SAWYTGESHH ASDAHVISGG VLLTLLCFII ACFSLTSSTS PRSRGGYYVG
LSDSGMPLYT YGEAFLQKTS RSIMLLIKET LAEILANTDS RRIFWFLCAN LSFCGIEFLY
GFWTNSLGLI SDGFHMLFDC SALVMGLVAS VMSRWPSSKY YSYGYGRVEV LSGFINALFL
IVIAFFIFLE ALERLYDPPD ISTDKLMIVA VAGLIINIFG MFAFHGATHA HSHGDDGSHS
HSHNDASHSH SHSHSHSHSH SHGEANANMQ GVFLHVLADT LGSVFVIIST LMIQYFGWKW
VDPLCSLILS MLILGSVIPL LKQSMATLMQ NMPPKTEEEF EHILHEILNM EGVISYSNVH
LWQLKSVFNI VSLHVQVSDD ANDQIIRLKI LKILKSINIT QASVQVEKEN FFHRISALCP
SYKIPQRITK GVAIGHTSVS GNFCHHNEVC D
//
