ID A0A0N4TU54_BRUPA Unreviewed; 1204 AA.
AC A0A0N4TU54;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Neur_chan_LBD domain-containing protein {ECO:0000313|WBParaSite:BPAG_0001230501-mRNA-1};
GN ORFNames=BPAG_LOCUS12267 {ECO:0000313|EMBL:VDN93453.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001230501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001230501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN93453.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; UZAD01013279; VDN93453.1; -; Genomic_DNA.
DR STRING; 6280.A0A0N4TU54; -.
DR WBParaSite; BPAG_0001230501-mRNA-1; BPAG_0001230501-mRNA-1; BPAG_0001230501.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18997; LGIC_ECD_nAChR; 2.
DR CDD; cd19051; LGIC_TM_cation; 2.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 2.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF410; ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-TYPE DES-2; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 2.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 2.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 2.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT TRANSMEM 265..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 318..336
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 348..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 609..631
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 884..902
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 945..963
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 995..1014
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 1168..1188
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 28..264
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 300..425
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT DOMAIN 665..883
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 926..1182
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 1204 AA; 139461 MW; 3BF000E6E29E388B CRC64;
MSVKHQVFIF KIFAALQAIS NYLPPQLKLV RDMLETYDKK SRPVWDHSRS INVTFSMDLY
QILQVDEPQQ YVLLNAWIIE RWYDEFLYWR PEDYDNITEI HLPHSSIWLP DTTLYNSSAH
FIYFNDHIIF NQLRLIMKDD DTRRLLNVKL TADENIRAAY IELLYPTIYK FSCLLNLRFF
PFDIQGKSKT NLNSVCSMIF SSWTFDQKGI DYFAYSDIVG TTNYIENEGW HILRTAVKKK
EVKYECCPNK YTLLSITLYL RRKPLFYIIN LIIPTSITTL IAIVGFFTHV FFFNLKKVFL
ESLVFRTSTA SGMREEKVSL GITTLLSMSI LMLMISDQMP TTSTFIPLIG WFILAMITII
TFGTLASSVI IAIQKRGRQK SRLTPRIVCL MKFIACIMLE DIPKHLRETH EKELKTTTLL
NEEGQHFPRI KQAAILQRRQ KTQAIEPHLC ELSTLSYNNN NNGTDLLSPK EAGQSVDISD
ILDPPMSSFC LRYDSLKGGN IGSKIITSEK PQRPSQNVSN TCEASAYSLI KLLILHRYCT
SIKFWNSRMN LHDFFKMRSV FDRTVGWHEM NMTGWQKYWN DCFSSCLSSF LHLSLLVSTL
WVFTIGAKWI MCCTIVNSVA MLLLFAATFA LSVTSLEIHQ SVSEVEKGDE MHYFISERQQ
LPHIRLIRDL LSTKRYDPSV RPVGNYSKSL TVHISMSLYQ VVDVDEPSQY LTLNIWMIQK
WVDEFLDWNP SEYDMINYTV LPHSALWIPD TFIYNRHSTS FVVMSREGSE RYMNVAVKSR
HWKDKCGAEV FFLYPALYTI RCRIDIRYFP YDHQNCTLTL GSWTSSKALL NYTTDKAVNM
HSYIPNEEWD ILSFNLYRHE YLYACCQDPW VIIEGSLIIR RKPLYYVVNL IIPTTILTLG
FFNLKIVKAS LNVADVSRVQ SGKCRMAIVG FFTPASTNDE RTEKITIGIT ALLAISILML
MVSDQMPTTS DFVPLIGDLI LGSICQISLS FPQQHFVLAL FSVFMAIIKT GNVLQRLKQK
KKSIQYTVQS LDKEKLTLTE LSVKSPMQGI LESETNKQAQ QGAQRLSAKE NWTQISFRLK
DILHKNRDRS EVIPKENSLT SLLQKMRKTS TVHSDRRNLS LWNSAVQFVR FTSNDLSQKP
ESAELKSMKY HRQCTLEWEF LATVVDRIFL LLFSTITILI IIVLAITAKL AQYRFNTALE
IAQN
//
