ID A0A0N4TUY8_BRUPA Unreviewed; 537 AA.
AC A0A0N4TUY8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE RecName: Full=RuvB-like helicase {ECO:0000256|RuleBase:RU363048};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363048};
GN ORFNames=BPAG_LOCUS12592 {ECO:0000313|EMBL:VDN93778.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001263001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001263001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN93778.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363048};
CC -!- SIMILARITY: Belongs to the RuvB family. {ECO:0000256|ARBA:ARBA00007519,
CC ECO:0000256|RuleBase:RU363048}.
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DR EMBL; UZAD01013305; VDN93778.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4TUY8; -.
DR STRING; 6280.A0A0N4TUY8; -.
DR WBParaSite; BPAG_0001263001-mRNA-1; BPAG_0001263001-mRNA-1; BPAG_0001263001.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.50.360; RuvB-like helicase, domain II; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027238; RuvB-like.
DR InterPro; IPR041048; RuvB-like_C.
DR InterPro; IPR042487; RuvBL1/2_DNA/RNA_bd_dom.
DR InterPro; IPR010339; TIP49_P-loop.
DR PANTHER; PTHR11093:SF6; RUVB-LIKE 1; 1.
DR PANTHER; PTHR11093; RUVB-RELATED REPTIN AND PONTIN; 1.
DR Pfam; PF06068; TIP49; 1.
DR Pfam; PF17856; TIP49_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363048};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363048};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363048};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363048};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363048};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transcription {ECO:0000256|RuleBase:RU363048};
KW Transcription regulation {ECO:0000256|RuleBase:RU363048}.
FT DOMAIN 109..425
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 537 AA; 58483 MW; 19E1E88B50195B35 CRC64;
MRIGLVRDEL DGSVTSTCYV RSGLMTIESN AALSTKLISI DEAISIRSRS VVKSTARKQR
VAAHSHVKGL GLDPETHTPS DNASGFIGQL EAREAAGVIV DLIRSKRMAG RAILFAGPPG
TGKTAIALAV AQELGDKMPF CPMVGSEVYS SEVKKTEVLM ENFRRSIGLR VREKKEVYEG
EVIELTPVES ENETGGYGKR ISHVLIGLKT VKGSKQLKLD PSIYDTLLKQ KVEVGDVIYI
EANSGAVKRL GRCDVYATEF DLEADEFVPL PKGDVRKSKE VVQDVTLHDL DIANARPHGT
AGNVTSLVGQ LLKPKKTEIT ERLRQEVNNV VNDYIEQGIA ELMPGVLFID EVHMLDIECF
TYLHRALEST ISPIVIFATN RGQCKVRGTE MVSPHGIPLD LLDRILIIVT KPYKIDEILA
IVKIRAEAEG VKLDEDALTY LSNLGAETSL RYVVQLLTPA KLLAQVNSRD SVTEEDVKQC
AELFIDAKAS AQLALSSISG DNTHTSPIAK LDSVATVHPL NCQTTSDGDP PMETDGT
//
