ID   A0A0N4TXA5_BRUPA        Unreviewed;      1067 AA.
AC   A0A0N4TXA5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   22-FEB-2023, entry version 25.
DE   SubName: Full=Importin N-terminal domain-containing protein {ECO:0000313|WBParaSite:BPAG_0001360201-mRNA-1};
GN   ORFNames=BPAG_LOCUS13530 {ECO:0000313|EMBL:VDN94715.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001360201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001360201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN94715.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the exportin family.
CC       {ECO:0000256|ARBA:ARBA00009466}.
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DR   EMBL; UZAD01013407; VDN94715.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4TXA5; -.
DR   STRING; 6280.A0A0N4TXA5; -.
DR   WBParaSite; BPAG_0001360201-mRNA-1; BPAG_0001360201-mRNA-1; BPAG_0001360201.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR041123; CRM1_repeat.
DR   InterPro; IPR041235; Exp1_repeat_2.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR045065; XPO1/5.
DR   InterPro; IPR014877; XPO1_C_dom.
DR   InterPro; IPR040485; XPO1_repeat_3.
DR   PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR   PANTHER; PTHR11223:SF2; EXPORTIN-1; 1.
DR   Pfam; PF08767; CRM1_C; 1.
DR   Pfam; PF18777; CRM1_repeat; 1.
DR   Pfam; PF18784; CRM1_repeat_2; 1.
DR   Pfam; PF18787; CRM1_repeat_3; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM01102; CRM1_C; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          45..111
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   1067 AA;  122655 MW;  F27F174AA6F5E516 CRC64;
     MTMMTVAALQ KAGEALLSSE KIEIPLLDQV VNIMNQSTGE TQQLASKILT ELKQKDTSWT
     RVDGILEYSQ LMETKYYALQ ILESLIETRW KSLPREQCEG IKSFIVELVI KISSEEITSP
     QIKTYLQKLN LVLVQIVKQE WPKHWPTFMA DIVGASKVND NLCLNNMIIL RLLSEEVFDF
     DGEMTQAKAY HLKKTFCSEF QAVFNLCYTV MESSDNAPLV DATLHTLHRF MSWIPIGYIF
     ETSLIDLLTK KFLGVAMFRC ITVQCLSEIA SLSVAQMEQQ NPLYVNQVKS LFRNSMVQIM
     NTIDPGVDLS DAYRRGTDAD QKFIANLAQF LGTFLKENSQ LVEVFGDKTD ELDLKNAHEM
     ALQYLLKISM VDDVEVFKIC LDYWNWLCAE LYREFPFQID RPIISALPMF VELQEAPRRL
     LYSNVLSELR LVMISRMAKP EEVLVVENDQ GEVVRELIKD TDSITLYKTM RETLVYLTHL
     DYKDTEMKMT EKLQNQVNGK EWSWKNLNTL CWAIGSISGA MMEEDEKRFL VGVIRDLLGL
     CEQKRGKDNK SVIASNIMYV VGQYPRFLRA HWKFLKTVIN KLFEFMHETH EGVQDMACDT
     FIKVAHKCKR HFVLTQAGET GPFIDEILGG LNSIICDLSP QQVHVFYEAV GCLISAQTDP
     AIRESLIERL MQLPNSIWEE IISHASQDIN VMKEQEVVKN IVNILKTNVA ACRSIGEPFI
     CQLSKIYLDM LNVYKVTSEN ISGLVAQSGE EVLKQPLLKQ MRAVKREILT LISTWVGKTQ
     DTNVVLENFV PPLFDAVLFD YQRNCSAARE PKVLSLLSII VSQLQSSINP EVIRILDAVF
     TCTLEMINRD MEEYPEHRLN FFSLLQALNH ECFDVLISLP PEHFRLIVDA VVWAFKHTMR
     NVAEIGLDIL KDMLTQFGVH RDKERAQTFY KHFFMEILVH VLTVVTDSNQ IKILAEISIT
     EQLNPPQSNI DYIYMHISET FAQAFDNLTP DQIRVTVKGF FSFNIDSVKM KNHLRDFLVQ
     IKERVGEDTS DLFIEEREQE IQNVQNAKKE VPGMLNPHEI ADDDSMK
//