ID   A0A0N4TYW7_BRUPA        Unreviewed;      1054 AA.
AC   A0A0N4TYW7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=SSD domain-containing protein {ECO:0000313|WBParaSite:BPAG_0001422401-mRNA-1};
GN   ORFNames=BPAG_LOCUS14152 {ECO:0000313|EMBL:VDN95337.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001422401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001422401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN95337.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; UZAD01013535; VDN95337.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4TYW7; -.
DR   WBParaSite; BPAG_0001422401-mRNA-1; BPAG_0001422401-mRNA-1; BPAG_0001422401.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF97; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        114..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        386..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        528..545
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        600..629
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        867..887
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        893..915
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        936..958
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        970..992
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          419..556
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1054 AA;  120453 MW;  7206B343F738E76F CRC64;
     MSQETKHPKE TATSVHWEKS KNQGEKNPKD DFSWNTERSN NVPKYSGIDY GNSWMHSQAY
     EDLSSQSLHG HRRSSILVGK RSMQLLEEFG EKEPKFVKFI IKIYNKWGFW ITRFAWPAMI
     SCILISLLAL IKISYTPQRN DLEGYSPFEA RSRIEYDKYL NFFSGRGLAI STYLYITAKD
     GNSMLRQSHL NDTIKVLHLA ANNITLYDPI TRNNQSFNQF CREFCNINEP VLQFYNAYMV
     QKWNVDNGDR PNPYLRLRYP ISTLFGREIS IQPYFFGVEL YNGNETKEDI DEEREGVHQL
     FGNDTNIDLL VAWNETHPAV TNMKSVKMIS LQLRALQNPQ WSKDDMKQWE MNVVHFFENY
     QSEHLTIYVA STTYIEEEMV RAGISLLPYL TAGFIIMCTC SVITVMVRAA YMHQNNVFKV
     FLAVMACATP LLACSTALAI LFLCGMRFSS ILCVIPFLVL SIGIDSSYLM IHEWQRVTKE
     IRDGEKKSGT VGHRMSEVLS EVGPAILISA ITNILADAVG CFTSSPEIRL LCIGNLFSMF
     MAYLYQMLFY SGLMSVVGKF EIAAEKNEDN ITNITIQKTQ RKNSRFHDKS KLYISKYMRV
     YVNIIAHASI ATLIIVLYIT YIIISVWGIT RMNISLTPQK LFAADSPLIK LDKLRVKYQI
     PFFTMASVFV ETPGDLSQKL PLLLMNNMVQ DFENLDGSWG PTGTMYFVRD FALFQSFLQS
     EHDYDFDSLD DVSTTTINPE DALKFNNDDL ANFLTWPEYD FWSGFVQLQN LSTDGKKKKL
     KRFFFTTAYH DENLKVWTTR GKLLKRWRAI VDKAMYESFH ASVFHEDAIF LDLIDNMPTD
     TWQSIAGTLI CMAAVCFLFL RNMLTVIIAT ASVLSVSIGI LGILSWWNVE LDPISMAAMI
     ISTGFSVDIP AHVAYHYCKA NEQSTPQAKL GNCLTSVGFP AVQAALSTIL CVYSLWFAGI
     YMSQVFVKTM VTSVILCNLH GLVVLPAILS IVHRVRGRFD QNKTYSTPAE RAVNKRLKQI
     RKRMAKTAEM QGINGHQPDL KMDRPPIPEF SIIP
//