ID   A0A0N4TZI8_BRUPA        Unreviewed;       516 AA.
AC   A0A0N4TZI8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN   ORFNames=BPAG_LOCUS14386 {ECO:0000313|EMBL:VDN95571.1};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001445801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BPAG_0001445801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN95571.1, ECO:0000313|Proteomes:UP000278627}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC       inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   EMBL; UZAD01013636; VDN95571.1; -; Genomic_DNA.
DR   STRING; 6280.A0A0N4TZI8; -.
DR   WBParaSite; BPAG_0001445801-mRNA-1; BPAG_0001445801-mRNA-1; BPAG_0001445801.
DR   Proteomes; UP000038020; Unplaced.
DR   Proteomes; UP000278627; Unassembled WGS sequence.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU368069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW   Signal {ECO:0000256|RuleBase:RU368069}.
SQ   SEQUENCE   516 AA;  58893 MW;  AC392FA688637A31 CRC64;
     MDEDRYLYSP LGIMFVTMGE NHEQVSFAYP FQNASTVTSE LQSFSSSEPY PTICAQSLKG
     SEERNSSDAE QYGVPTKILS HLLSARGICE KPFEIKIDNI RFAGFPKTVS HPTGRSPQTF
     HVVFILTAKV TADLVTSFQE LSRKIAIAID EEQTRCDYLA DQMTIILNEH EKNESLPEGQ
     AFPYHEVLAH CSLAQDLRDI FSDVSEHGVV HVFLNDCIEV GFCVEPRALL HAGLTPKTRS
     EIEATIRRLR PYHGILLLED AIPGHDSNPA LHFFLKHCHP DQSLISISDS SGLSLFQVLT
     VVRHLLLWAR AIVIYPLCSS NVYTSATSPK PLSRLSEQFS EIFENAHLPT ILAQFSPPCT
     LEEFTNASMY SFSEQTKTHY FQQLRIRMVA RLLRDELIMQ LHTFLYLMPP FSHEIIDEST
     MDIDQDDHLN RLLSSVMLTT EVKASVIQVY KTMLKRHPQQ YAEDLLDLFL KLVPYLRGEH
     HVEDIMYRMN LERSSIMRVL DTFACVIAPF MRPEYV
//