ID   A0A0N4U509_DRAME        Unreviewed;      1236 AA.
AC   A0A0N4U509;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN   ORFNames=DME_LOCUS6268 {ECO:0000313|EMBL:VDN56295.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000190801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000190801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN56295.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the MADD family.
CC       {ECO:0000256|ARBA:ARBA00005978}.
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DR   EMBL; UYYG01001155; VDN56295.1; -; Genomic_DNA.
DR   STRING; 318479.A0A0N4U509; -.
DR   WBParaSite; DME_0000190801-mRNA-1; DME_0000190801-mRNA-1; DME_0000190801.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR039980; MADD.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT   DOMAIN          26..493
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          587..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1236 AA;  138900 MW;  C69584C8989510A4 CRC64;
     MDDKGKELCP RLIDYLVIVG RRSRSKCFSQ LSIDGASSSQ SVTAPELLRR YPTDDHKDFS
     LPTDVTVFCQ PEGCIIRGAP RRTQSLPDGN SFVFTLTEKD SAKIRYGICF NFFQSFERPK
     ANIDSNADVS NEKKFRRRMS LTSLCLISHH PFLSTFRELL LLLKKLIDGY NFNFRDSVWS
     ALTGHWGDTI PPPVMYEIRE LETWILMILS TPVPVPGKTK VQLEVMPLNI VPMLEFALPD
     HTRFSLVDFP LHLPLELLGI DTAVKVLAAV MLEYKVVLIS RNYNAVSMCV LAIVSLLYPL
     EYMFPVIPLL PSYMLSAEQL LFAPTPFIIG MPASFFSQKN IDSVPNDVIL VDLDTNQLII
     PESITIPDMP EPDCSILKQS FRNALAKLKL ASLDFDLDKG GNDFEASFIV DSDVVDVAVR
     VAMIHFFNSS NIFANFSEHT RTLRLYPRPV VALQTESFLR SRPNFTQFIL ELCRSTQAVE
     YFAESSLCPR NETYVRVQTG IEAPEQIGDK GKWFSEALMP VHFAAYPNDS TLADAWHVFL
     TAEQKNTLVI IAMLFLFEEA SKPLAEVNDI YREPLTLELP RNDSSLSIGS SLSSGRSTPS
     SMSTSAMDSE ADFARLAENL AIKTDAKGIA HLTDSGEKVL GPQLMSALNG YAEKSHDMIN
     QMLHRTAPKA QAFRDKTVGP IAAAAANRME QSQHLVKTKA KIFNVLSFEL SNFSKNQQIV
     RDVCDQVLAG QGIGVFTYAK LRRLMEDESL RQLVCSKLNL GLDIKHSEED FVQEMQLMKS
     QYKGYIKVLQ TCINGLDYSF ITPGSNGLAS MFHILEIAHT HFWAKESDIT TPLSGIASQA
     LSISDYSGPF CIEKIFTYGP PPPLPPRPKK STDEAMKRLS ITNDSISVFP LTSRANSLGA
     IEPLLQLQPP KSLPISRESI VTVNRSPDCP RHYIYQDLIL PSPNPLWHKM AFWESAFFDV
     VAQERDIIGM DQEPCEMIDR YSGLSESEKR RLELDEDRLL ATLLHNLTAY MIMCGTGQKA
     IQQKIRRLLG KAHIGLVYSK TINHLLDHLP QTQSNGIPLK PLGSRLMQKQ SFTVYSGSNA
     DGSMMFLEVC DDAVVLRAVT GAITERWWYE RLVNMTYSPK TRVLCLWRRH EGKVHMHKFY
     TKKCRELYSC MKTAMERAAA RGKVPIAGKG DLGGEFPVHD AASNEGGLLQ VRIDGVYNKY
     LIAQHNLIHF IDLANIKKCN TFGGNVFILE EYGDFF
//