ID   A0A0N4U887_DRAME        Unreviewed;      1040 AA.
AC   A0A0N4U887;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Host cell factor 1 {ECO:0000313|WBParaSite:DME_0000324301-mRNA-1};
GN   ORFNames=DME_LOCUS7402 {ECO:0000313|EMBL:VDN57429.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000324301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000324301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN57429.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; UYYG01001160; VDN57429.1; -; Genomic_DNA.
DR   STRING; 318479.A0A0N4U887; -.
DR   WBParaSite; DME_0000324301-mRNA-1; DME_0000324301-mRNA-1; DME_0000324301.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 6.10.250.2590; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR043536; HCF1/2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   PANTHER; PTHR46003; HOST CELL FACTOR; 1.
DR   PANTHER; PTHR46003:SF1; HOST CELL FACTOR; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   Pfam; PF13415; Kelch_3; 1.
DR   Pfam; PF13418; Kelch_4; 1.
DR   Pfam; PF13854; Kelch_5; 1.
DR   SMART; SM00060; FN3; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF117281; Kelch motif; 1.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          367..879
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|SMART:SM00060"
FT   DOMAIN          895..990
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|SMART:SM00060"
FT   REGION          647..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        660..711
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        734..769
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1040 AA;  113458 MW;  90B77B9E22464EEF CRC64;
     MDSDRRDPMV GTSFSNFPSV RWKKVTNTTG PTPRPRHGHR AVAIKDLMIV FGGGNEGIVD
     ELHVYNTATN QWFVPAIRGD VPPGCAAFGI ICDGTRIFLF GGMVEFGRYS AELYELQASR
     WQWKHLRVRP PKSGSAGPCE RLGHSFTLAS NQVCYIFGGL ANDSPDPKNN IPRYLNDLWA
     LDLKYGTNNL QWECPSTFGT GPSARESHAG VMFEKDGYRK LIIHGGMDGC RLNDLWILDL
     NSMTWSNPQP EGIPPLPRSL HSANIIGDRM FIFGGWVPLV LGDSKMDQIE KEWKCTNTLA
     SLDLNSMCWE TLSTEIYEDA LPRARAGHSA VVINKRIYIW SGRDGYRKAW NNQVCCKDMW
     FLETDRPAAP SKIQLVRATI CGLEVCWNSV PTAEAYLLQL RKYESTPRGT EDGARAVGMV
     RMSAAKSQIS SNKLIAIQRS SGGPQVMKVV RSGPHLSSGV ITPTSGGSLL RVVSASKGPQ
     TTATSIPKSG TKTIIVTKAT GTGTAARKLF LVQPSTSSGS SVGGVRSNTQ LSLVDSVPQR
     ISSKASSVAV VGSEHTSTIS THGTTYTSPM TSNVDTGLPQ NLLDESLMET DSGMGQPDSV
     DQIQEPSDSY RTSQVVEFMP TEQASTSLSS ETTQGLNDGV TPEITHDSEA PVEQKINQSS
     KEIQNEENEI KSTEDLLGLR NSDEIKENSD HVKENFGKQE IPADDMKESI TESQNIESGD
     GVVPFFKVEA PESSVSDNLV NPSASESKSG ENTVESSDNM PVSSTAPSVA DVASENSVAC
     DSKVTQTLKV VKVEATSTQN EPYPVKEDPP WFDVGIIKGT SCVVTHFFLP SDMPLEDTYS
     TDFEVGMHTS QVGLLRKAEL EPGTAYKFRV AGINACGRGE WSEVTAFKTC LPGFPGAPSN
     IKVSKSVRGA HLSWDPPHNI GGRICEYSVY LAVRSSHMGN ETQLAFVRVY VGPESSCVVS
     TTDLQVAYID MASKPAIIFR IAARNDKGYG PATQVRWLQD QRQRLPPVIG RQSQPLHQPM
     VNDYHGISPV HIQAKRMRLE
//