ID A0A0N4U8I0_DRAME Unreviewed; 674 AA.
AC A0A0N4U8I0;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=P/Homo B domain-containing protein {ECO:0000313|WBParaSite:DME_0000335301-mRNA-1};
GN ORFNames=DME_LOCUS219 {ECO:0000313|EMBL:VDN50246.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000335301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000335301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN50246.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYYG01000002; VDN50246.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4U8I0; -.
DR STRING; 318479.A0A0N4U8I0; -.
DR WBParaSite; DME_0000335301-mRNA-1; DME_0000335301-mRNA-1; DME_0000335301.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884:SF23; FURIN-LIKE PROTEASE 2; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..674
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033230529"
FT DOMAIN 483..621
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 213..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 194
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 233
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 407
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 674 AA; 74867 MW; 1F1A1B44020D358F CRC64;
MFWRFMRVLL LTISITSVLS IEHDSVCDES KEWKCPEPSH TIMRLKKRDD NKAKEIAEYH
GMEIVGQPFL DGSVYFVEHK KHRTRRRKRE IVGKINDHPD VIFVEEQRPR QVFSVFLLIR
RKRDFTHPNI RSALPNPEQI IGEPTVFPAL PFPDPLFREQ WYFNGGAHGG YDMNVRDAWL
AGYAGRNVSI SILDDGIQRD HPDLAINYDP LASADINDND EDPTPQDNGD NKHGTRCAGE
VAAVAGNQYC GVGVAFHAKI GGVRMLDGPI SDAVEAASLS LRQDHIDIYS ASWGPEDDGK
TFDGPGPLAR EAFYQGIKNG RGGKGNIFVW ASGNGGARQD SCSADGYTTS VYTLSISSAT
FDNRQPWYLE ECPSSIATTY SSANLNQPAI VTVDAPRGCT RSHTGTSASA PLAAGIIALA
LEANPNLSWR DMQHIVLRTA NPVPLLKNPG WSINGVNRHI SNKFGYGLMD ADALVKLARV
WKTVPEQHMC TYNYELKAPK PRPLTGRFQI NFTLEVSGCS SGTPVLYLEH VQVYATIRFG
KRGDLKLTLF SPRGTASVLL PPRPQDYNSN GFHRWPFLSV QMWGEDPRGV WTLMVESVSA
NNKIGGTFHD WSLLLYGTVE PAQPSDSRYS PQPYSSNDPS KSFLERTASR ITSQVSSRPH
INAHRSLAQN LTLS
//