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Database: UniProt
Entry: A0A0N4U8I0_DRAME
LinkDB: A0A0N4U8I0_DRAME
Original site: A0A0N4U8I0_DRAME 
ID   A0A0N4U8I0_DRAME        Unreviewed;       674 AA.
AC   A0A0N4U8I0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=P/Homo B domain-containing protein {ECO:0000313|WBParaSite:DME_0000335301-mRNA-1};
GN   ORFNames=DME_LOCUS219 {ECO:0000313|EMBL:VDN50246.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000335301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000335301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN50246.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC       {ECO:0000256|ARBA:ARBA00005325}.
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DR   EMBL; UYYG01000002; VDN50246.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4U8I0; -.
DR   STRING; 318479.A0A0N4U8I0; -.
DR   WBParaSite; DME_0000335301-mRNA-1; DME_0000335301-mRNA-1; DME_0000335301.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR034182; Kexin/furin.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR032815; S8_pro-domain.
DR   InterPro; IPR038466; S8_pro-domain_sf.
DR   PANTHER; PTHR42884:SF23; FURIN-LIKE PROTEASE 2; 1.
DR   PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..674
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033230529"
FT   DOMAIN          483..621
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   REGION          213..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        194
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        233
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        407
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   674 AA;  74867 MW;  1F1A1B44020D358F CRC64;
     MFWRFMRVLL LTISITSVLS IEHDSVCDES KEWKCPEPSH TIMRLKKRDD NKAKEIAEYH
     GMEIVGQPFL DGSVYFVEHK KHRTRRRKRE IVGKINDHPD VIFVEEQRPR QVFSVFLLIR
     RKRDFTHPNI RSALPNPEQI IGEPTVFPAL PFPDPLFREQ WYFNGGAHGG YDMNVRDAWL
     AGYAGRNVSI SILDDGIQRD HPDLAINYDP LASADINDND EDPTPQDNGD NKHGTRCAGE
     VAAVAGNQYC GVGVAFHAKI GGVRMLDGPI SDAVEAASLS LRQDHIDIYS ASWGPEDDGK
     TFDGPGPLAR EAFYQGIKNG RGGKGNIFVW ASGNGGARQD SCSADGYTTS VYTLSISSAT
     FDNRQPWYLE ECPSSIATTY SSANLNQPAI VTVDAPRGCT RSHTGTSASA PLAAGIIALA
     LEANPNLSWR DMQHIVLRTA NPVPLLKNPG WSINGVNRHI SNKFGYGLMD ADALVKLARV
     WKTVPEQHMC TYNYELKAPK PRPLTGRFQI NFTLEVSGCS SGTPVLYLEH VQVYATIRFG
     KRGDLKLTLF SPRGTASVLL PPRPQDYNSN GFHRWPFLSV QMWGEDPRGV WTLMVESVSA
     NNKIGGTFHD WSLLLYGTVE PAQPSDSRYS PQPYSSNDPS KSFLERTASR ITSQVSSRPH
     INAHRSLAQN LTLS
//
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