ID A0A0N4UDF2_DRAME Unreviewed; 388 AA.
AC A0A0N4UDF2;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase {ECO:0000256|ARBA:ARBA00016920};
DE EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN ORFNames=DME_LOCUS9159 {ECO:0000313|EMBL:VDN59186.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000536001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000536001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN59186.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate
CC biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
CC {ECO:0000256|ARBA:ARBA00005084}.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; UYYG01001177; VDN59186.1; -; Genomic_DNA.
DR STRING; 318479.A0A0N4UDF2; -.
DR WBParaSite; DME_0000536001-mRNA-1; DME_0000536001-mRNA-1; DME_0000536001.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 1.10.3270.10; HMGR, N-terminal domain; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR023282; HMG_CoA_Rdtase_N.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756}.
SQ SEQUENCE 388 AA; 41994 MW; 429F59E488B78B7F CRC64;
MVKILKKKIE IVPFDHSVQG ACCENVIGYM PVPTGFAGPI LVNGRNYCIP LATTEGALVA
SVSRGCRAVS RVYADGMTRA PVVQFGSFLR ALYVSRSLQY LIYLFEKFVF FSFAKLIHLQ
VLPNDRELYL RFVASTGDAM GMNMVSKGVN AVIPFLKKNF PDMEVLSLSG NYCVDKKASA
INWIEGRGKS VISEAIISAS VVQSILKTDV DSLVNLSITK LQKGSSMSCT IGGWNAQAAN
IVAAMFIATG QDVAQVVSSS MCFTTMEKNS SGDLRISCSM RCLEVGTVGG GTFLPAQKAC
LQLLDCAGGN KISPGANSKL LAEIICSTVM AGELSLMAAQ CTNDLVKSHL RLNRSGILMH
LRQFKSKGHI DSKKTMNKTF ERQEIISF
//