ID   A0A0N4UDL4_DRAME        Unreviewed;      1285 AA.
AC   A0A0N4UDL4;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 3.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Helicase SKI2W {ECO:0000313|WBParaSite:DME_0000542901-mRNA-1};
GN   ORFNames=DME_LOCUS9228 {ECO:0000313|EMBL:VDN59255.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000542901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000542901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (MAR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN59255.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYYG01001178; VDN59255.1; -; Genomic_DNA.
DR   STRING; 318479.A0A0N4UDL4; -.
DR   WBParaSite; DME_0000542901-mRNA-1; DME_0000542901-mRNA-1; DME_0000542901.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.3380.30; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016438; SKI2-like.
DR   InterPro; IPR012961; Ski2/MTR4_C.
DR   InterPro; IPR040801; Ski2_N.
DR   PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR   PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF08148; DSHCT; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF17911; Ski2_N; 1.
DR   PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01142; DSHCT; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          355..511
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          580..750
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1285 AA;  146895 MW;  093AFE9317829CCB CRC64;
     MVNENEDGWL KTSDNDNNKS EIPANNDLLK ECEEEAEKVF RFSAIKYITE NFDEFDLSST
     YKIPPINDDI ESLYKDLLFY SPISYEIRLL RNIENDEITG FEEVYDNFAE YGDARVSMSL
     NRLPDAKALS SIMGSSTNVP FMPGGFDESL DSILQLSDLT LEPDSDESQF INFEKLKNSE
     LLSLAPGISC DVDQSNLEND LSNQSSTTFK ADNSRSIDID LGIPTIDLDN ADLFDLMNFS
     DVGDSIVAQS SIHSKNDESI DIETDVVHNN LKVQELETQE LSNSLKDLET TEIVENTGIK
     RISSKTMKQF QESEEKFLYA KLLASSGNIP EFEKLKANMA REYPFDLDPF QQQALICLER
     GDSVFVAAHT SAGKTVIAEY AIALCHLHKT RAIYTSPIKA LSNQKFRDLK SIFDDVGLIT
     GDIQLHPEAF AIVMTTEVLR LMLYHGSEVI RELEWVVFDE VHYINDSERG HVWEEVLIML
     PAHVKIVMLS ATAPNCIEFA DWVGRIKNRK IYVILTSRRP IPLEHYLYTG QDGKTRKDLF
     MLVDRTGQLL NKGYYKAMEV KSKLRKQTSG PLNFRPNSKN DKNIYINLIS HLNSENLLPA
     VIFVFSRQRC DEYASLLQSV DLTTAKEKDE IHHFFTRCIS HLKGSNKKLP QVLFSTETFA
     MGVNMPARTV VFDSIKKNDG QQWRFLNPGE YIQMAGRAGR RGLDTTGTVI VLCKEPILPE
     LSELDYLMLG KPVQLRSQFR ITYNMLLNLL RVEHLKIEDM LHRSYIESAS LRQALFRRSL
     LNEMQEKLRS FPPIDCTLCA NGDSEFASSL FSFHKFLREF VKRRSSLWVD LSNHLVTNKI
     LSCGRLIMVS LPDRNISATF AIVLKVTVEQ NAWRMELLIP SSGDRALEIT EKKIIDEFNR
     MSDKEKEWKI LTALMESAVT GNLESFNWPQ NNDWSTCRII NCIPIRYLIA ISQTTIKLDV
     NAIVDAYRTT NQQNFRTDIS DCVLARVFHQ MENLVRKITS DKKCKIILPG REIQVGEPTL
     FSEVLRLNEL RAILSTENRF SCCRCFSFHK HLWMLHEKIK LEEEIEELSL SLSSSGLSLS
     QDYLDRLKVL RQLQYIDSSN LITMKGRVAC ELHHQEIIIT ELMLDNKLQN RTPAEIAAIL
     STTTSTQQKK INDARVDNEQ SENAYNLPVF NELKSDVTLV AERLAHVQRE CGLRCVDPIE
     ELNFDLMHVV YEWSNGTPFA KIMEITDYQE GIIVRCIQRL DEICKEVRSA ARLVGDPSLF
     EMMGVVSQSI RRDIVFAASL YTVSV
//