ID   A0A0N4UDP2_DRAME        Unreviewed;       893 AA.
AC   A0A0N4UDP2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=SSD domain-containing protein {ECO:0000313|WBParaSite:DME_0000546001-mRNA-1};
GN   ORFNames=DME_LOCUS566 {ECO:0000313|EMBL:VDN50593.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000546001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000546001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN50593.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; UYYG01000005; VDN50593.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4UDP2; -.
DR   WBParaSite; DME_0000546001-mRNA-1; DME_0000546001-mRNA-1; DME_0000546001.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF112; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        370..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        683..705
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        717..736
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        756..775
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        782..806
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        867..888
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          239..396
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   893 AA;  101564 MW;  99192A491257B37F CRC64;
     FYILLNILNF HFIIIFRVAI TIVLSTGAIN FREVNNVRED FSAINAPSRY EYAVTQDFFK
     NFGSPFHLVV VFEAMDGGSL LRPGYLEKAI EIEEYLQTKL NISQEGQTYS YSDFCQPYCE
     TSDVVNIFLN MYRAVEIRKK TKVKLTYPTM DLFGHRIYLA NNIFKVDLYE RSQLIKGCGI
     IAINFHAIIS NDSQAEIINK WEHEVLKFAS STKNNNLIRV YATSEALVSE EIRKTGIQAI
     PLISISLIAV LIFTILTSLK CDPITSKPFE ALLGVFCPLI SMFASFGALF WLDYPFLPIV
     CVVPFLILAI GVDDVFIFLH CYHRSNRKLC VEERIANMLA EAGPSITITS LTNFLSFSIS
     ALTPTPAIKI FSIFISVAVV FDYIYQIFFY SAVLTLGGRR EEKKLNAWIL CSNIPIKREV
     FYGKKVRIWL SKTMRDFVHT WVNFSMSVAA RIIISIILVI YWIISAYGLF QIKVGLSSEK
     LFMDDSEILP FVKIQSTIIF KEGGQVLVFV NKPGDLTEKE AVPKIMQLLN RFEKASGSVG
     PISTHMWLFS YLPYTGIQNK GSIEFKYKYL PEFLSFREYH RWNYFLSLGS TEDCLQEKPS
     CVQKFFFTTG FKGAVAWSDR LKLLIEWRAI ASEYKHLNVT VYEPFSMYAD QLLTIVPVTK
     STVTFAFICM AIVLTIFTPC ITTIITSTLS ILSINLGVIG SLTYWNVDLD PISMATTLMS
     IGFSVDFIAH ITFHYYKGEQ PDKKERLRHA FNSIAWPMMQ AGVSTILSLC VLAIIQAYMV
     KVFVKVVVLV VMLGLFHGLI VLPIVFGALP INKKNSLLSS SNSQKVFISS PFLCVHVIRV
     DMQIPLKMDL KVTGRRTNVQ PDNHGDILIS VNFIFYIVIN VCVEFFYIRN SNV
//