ID A0A0N4UEE9_DRAME Unreviewed; 673 AA.
AC A0A0N4UEE9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=EGF-like domain-containing protein {ECO:0000313|WBParaSite:DME_0000575001-mRNA-1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000575001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000575001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A0N4UEE9; -.
DR WBParaSite; DME_0000575001-mRNA-1; DME_0000575001-mRNA-1; DME_0000575001.
DR Proteomes; UP000038040; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF00008; EGF; 2.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 594..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..79
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 496..535
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 537..578
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 69..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 525..534
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 549..566
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 568..577
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 673 AA; 75973 MW; 81AABB78C0C0026B CRC64;
LISEFPHGVS FLRKYHRMPK IPKIPEPKQK YQLAAFESGA QNFNPCKITQ LCQNGGKCIA
HQGAYYCQCS EEFYGKTCEF LANKSACENN LCQNGAICYS VKEKNQIIVN KDKSQINAEN
PNFKKSGIIQ SVQYECWCRP GYTGSLCEYS EKLRSCQEDF CLHKGVGHLS NHSGVMKCDC
LCDDNYAGER CQIALPCMDY ECFNGGKCNN ILIDTTEDGT GIYKAKCECL DRAVHGVAAV
FRGEHCEIIE ITSEMRAQFD DCFPCKLPIK DYLERCIDEY SQKFFYRKLR EIMESCKEPI
CTNPKQFCLN GGVCEIQGKQ ADDSKETILF PTCRCSGLDE GLLCQKHVAS PCDPTSFDPR
GHGEKCGKHG SCVAKTVYDY ICECETEDPC QYNLCSPGSL CVTLPIEKKE SYELGYICIC
DMNQEPDFSG HDNETMKCSL ADFGLCKNHQ CKENGKCYPC DKTDEENLQL CNDEEKSRGF
RCICPSGSLP PFCDKIADAC YGNKCLNGAE CVVDSRNQYS YICKCRLGFT GELCESETSP
CVSIGLKTCV MGKCIQDNGF ARGFRCDCIE GYDGLDCDLL DKANILDFYN RNFWWTYPLT
MSALLTPTIM ALTIIAENRA RRDYELRLIE KNQREELEVG KNEDGENEAR TTRINNLTEL
QTILHDFITH VSE
//
