ID A0A0N4UEU1_DRAME Unreviewed; 1047 AA.
AC A0A0N4UEU1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=TIR domain-containing protein {ECO:0000313|WBParaSite:DME_0000591601-mRNA-1};
GN ORFNames=DME_LOCUS855 {ECO:0000313|EMBL:VDN50882.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000591601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000591601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN50882.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; UYYG01000009; VDN50882.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4UEU1; -.
DR STRING; 318479.A0A0N4UEU1; -.
DR WBParaSite; DME_0000591601-mRNA-1; DME_0000591601-mRNA-1; DME_0000591601.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 868..1009
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1047 AA; 120332 MW; 28CEFE4ACF267FDF CRC64;
MRRRRCQCIN DILEENRQII TCKWSRILPD INLFYNFPYN ITKSLMIECV NDENDYHNRR
IESQFNDDIF KNFYNLQNLK IKNCRVRQLT RHLFRGLNNL RSLSLYNLSL KNSSLIISDG
IFDNLLKLEK LFIVNSQIQA IPSKALCRSP NLQILNISSN WLTAVNLGVN DCIRPMEQLI
IIDLSLNAIK SIAANDFKSL TNIRQLILSS NNINYFHHAS VNRLNIIPST ITNLINLISL
NISWNKIDIN TPFELHAKYI EILDLSGNYF NTIPVVIINN SINTLIHLKL TNNHIKNLNY
TTLVNFSRLE TVESYILSNI PRLSRMILSN NSINSIASDA FNKCPRLIEI DLSNNLISHI
TNDTFLNIGP KITRIILNNN LIELLQWNQL PSTLRTIELS NNLITRIDSA FKSNIKYVKL
DSNRMMMLTS EQIPSTAEYL NISHNLLDNL PNATFLNKSL KILDISFNNF NRINYYSFTN
NNNNNDGDTS IEIFIEGNPL ICSCEMNWLI SNDNNYAQVP LISSSPLLLP VTGGGNLRIK
DKHLATCKHR IDKRNIPLLK VKDDDLLCNY KQICEPGCIC CQYGNCDCKS KCPSGCNCYH
NSNYSINIVR CLSLNNTDRS NFSPKDLPMY ATNIFLENMH IPIIRSHDFL GRTRLLKLYI
NSSSVEEIQP LAFNTLPSLM LLDLSGNKLT TLTGDEMYRT NKVTHLFLNS NHLTSLHEKL
NREMPLLQYI TLHDNKFKNI PEIIDKKIDF AGLSLGQNPY RCDCDNRFRM QSWLIENIKV
IADVKDIFCI ENITEAFLKN DTTILSAYPP NIGHEIYAVP MLQFIENINK IKMVLKAKQE
RRRYKLPVKT VTTTTPITLS SSSPVPLINY DAFISYSKKD EKFINDIICR QLESEDYLLC
LLHRDCPNYN TDCAIKLHSV CDELIRQIDY SQSLIIVLTK NFLENEWGTL QIKTSHCLFA
KNRTKKLIAL LGDGIERNEL DHELGRILRK NTCIRINDPL FWNLLHSSLP LKINFYNDAG
GAIPGHSNNS SQIYSDCYGN IVPSNII
//
