ID A0A0N4UIF8_DRAME Unreviewed; 267 AA.
AC A0A0N4UIF8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=CoA_binding domain-containing protein {ECO:0000313|WBParaSite:DME_0000739101-mRNA-1};
GN ORFNames=DME_LOCUS10029 {ECO:0000313|EMBL:VDN60056.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000739101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000739101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN60056.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYYG01001200; VDN60056.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4UIF8; -.
DR STRING; 318479.A0A0N4UIF8; -.
DR WBParaSite; DME_0000739101-mRNA-1; DME_0000739101-mRNA-1; DME_0000739101.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 2.
DR InterPro; IPR017440; Cit_synth/succinyl-CoA_lig_AS.
DR InterPro; IPR033847; Citrt_syn/SCS-alpha_CS.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR005810; CoA_lig_alpha.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005811; SUCC_ACL_C.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR11117:SF2; SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11117; SUCCINYL-COA LIGASE SUBUNIT ALPHA; 1.
DR Pfam; PF02629; CoA_binding; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR PIRSF; PIRSF001553; SucCS_alpha; 2.
DR PRINTS; PR01798; SCOASYNTHASE.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52210; Succinyl-CoA synthetase domains; 1.
DR PROSITE; PS01216; SUCCINYL_COA_LIG_1; 1.
DR PROSITE; PS00399; SUCCINYL_COA_LIG_2; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Signal {ECO:0000256|SAM:SignalP};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..267
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033231748"
FT DOMAIN 19..114
FT /note="CoA-binding"
FT /evidence="ECO:0000259|SMART:SM00881"
FT ACT_SITE 225
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001553-1"
SQ SEQUENCE 267 AA; 28358 MW; 6EC3A3C3ADC6C129 CRC64;
KFIILKLIVV KFSLLLFGKK NFLKVLVQGF TGSQGTYHSK LMMEYGTNVV GGISPKKAGI
RHLGKPVFQT VKEAREKTGA DATIIYVPSA TASDAIKEAI DAEIPLIVCV SEGIPQHEMI
RTIQLLRERK VSRLLGPNCP GIIKSGECKM GIMPGDIHRK GCIGITSRSG TLTYEGVQQT
SSLALGQTHV IGIGGDPFKG SDFIDCLKVA FIAGMTAPKG RRMGHAGAII TGDKGTAQSK
VDSLKDAGVT VVNAITALGD AVLRELK
//
