ID A0A0N4UKA4_DRAME Unreviewed; 410 AA.
AC A0A0N4UKA4;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Flotillin-1 {ECO:0000256|ARBA:ARBA00026228};
GN ORFNames=DME_LOCUS10275 {ECO:0000313|EMBL:VDN60302.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000813901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000813901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN60302.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC functionally participating in formation of caveolae or caveolae-like
CC vesicles. {ECO:0000256|ARBA:ARBA00025336}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane,
CC caveola {ECO:0000256|ARBA:ARBA00004543}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004543}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000256|ARBA:ARBA00007161, ECO:0000256|RuleBase:RU366054}.
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DR EMBL; UYYG01001209; VDN60302.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4UKA4; -.
DR STRING; 318479.A0A0N4UKA4; -.
DR WBParaSite; DME_0000813901-mRNA-1; DME_0000813901-mRNA-1; DME_0000813901.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd03399; SPFH_flotillin; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806:SF47; FLOTILLIN-1; 1.
DR PANTHER; PTHR13806; FLOTILLIN-RELATED; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT DOMAIN 69..253
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT COILED 180..315
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 410 AA; 46006 MW; D640D0AE954F8C89 CRC64;
MFHSSPLYII GGRAFVFPII QMVQRIPLNT ITLEVISPRV YTQKGVPISV TGIAQIKIES
RKKEILAIAC RLFLGKTEIE IKQIALETLE GHQRAIMGLM SVEEIYQDRK KFSEKVFEVA
KCDLINMGIS VVSYTIKDIR DDHGYLKALG MKRTAEVKRD ARIGEAQATR DKIIKVMEVA
AEEQRMIAKY KNDIEIAKAK RDFELKQAAF NYDVNVNKAK ADFAYQLQAA KTKQNLKEEN
MQVAIVERTS AIEVAKEEVI RKEQELNATV RRPAEAEKFR LEKIAEAEKE KIILNAEAEA
EAAKLRGQAD AYAIQVKAAA DAKQIREKAE AFKEFKEAAI TEMTINMLPK LANKVGESML
DGVNEIKMVS TGQSDIGAAK ITGEMVSIME KIPQLMSNVT GVDLFRGQVY
//
