ID A0A0N4UL83_DRAME Unreviewed; 3882 AA.
AC A0A0N4UL83;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=DHC_N1 domain-containing protein {ECO:0000313|WBParaSite:DME_0000854401-mRNA-1};
GN ORFNames=DME_LOCUS2500 {ECO:0000313|EMBL:VDN52527.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000854401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000854401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN52527.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; UYYG01000064; VDN52527.1; -; Genomic_DNA.
DR STRING; 318479.A0A0N4UL83; -.
DR WBParaSite; DME_0000854401-mRNA-1; DME_0000854401-mRNA-1; DME_0000854401.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT DOMAIN 1868..1963
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2173..2350
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2548..2698
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2887..3057
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 535..562
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1205..1232
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3175..3220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3369..3431
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3882 AA; 444990 MW; 0EAD006CFFF89879 CRC64;
MTDSESDKST VINSNNQAPN EVILIDLSVL INYIKQIFVG AINEQLEDFL KQTSSIESFQ
KFISDPQILI LIIDRIIVRD TNPDDSNDEI SIIFRVSNEI VKRAERTTSI LLLKTGSIIE
ADKPVEDQLY SLRIPENNAY DVLLSIFGKI GTRLFKSLVD YGRGERDGDK LALSVEKHLS
EVEVALLHMQ QNIDIPEINL AINPVIQSTI QQAAEQGRKA RVSDLGDLVE SSVFLNALQK
GVNRWVKEIQ KVTKLDRDAG SGTSLQEMTF WLNLERALHK IAQKRESDEV ILTLEALKCG
KRFHATVSFD ADTGLKQAMA MVNDYNILMK DLPLNELMAA THMDAIRNAL INIFTHMKKL
RNTKYPIARA LRFVEAISKD VFTQMLKVLG TRRLMNIPLG DFDALMTQCF SVFSTWNDEY
DKLATLMRDL SKKKRDEQLK LTWRINPQHK KLESRLDQMR QFRRQHEQLR TVISRVLRPS
GLNAEDKPSH DAAGAGDAEK MLALNVGDSS AIDQINMAYE NVKEVDCLDV SNDGVAAWEA
ALRRYEDQID RVETQITARL RDQLGGAKKA DDMFAIFQRF NALFVRPHIR GAIREYQTQL
IQRVKEDIDQ LQTRFTNFSE TDNARILKSI DIPPVAASII WIRQIDRKLT HYMKRIEDVL
GRGWENHVEG RQLKLEGDNF RQKLNAQNIF EEWVGRVQSK NISLAGRIFN IEKRQKDGKI
SLKLKVNFSP DVVTLFKEVR NLKHMGFRIP LKIVNTAHQA NILYPFAISL LESIRTYDSI
NERIAGNDGI NMLIASYKKD IQNQLAEGNM LIWESYKMDP YVVKLSQSIN IYQEKVEELD
LLMTRIEVDL AALDTCQYSS VTFASLLASI QKAVDQLSLG NFSNLHHWVE NIDKKIELKL
ASRVEAAILL WTTVLTHEEM DDENEEKIVL PAVQPVLLEM RVTSQVLYVS PNIEQARAQL
LDQLFSWQSI ITNQSRISST RFQLALSREN TEATYRDVLA RLPQGQKILE RAYTAVEKVI
KDVSDYVGEW LRYQALWDLQ PDVLYERLGN NVSKWIQTLL EIRKSRATFD TQETRKEIFP
VVVDYRKVQS KVSLKYDYWH REILQKFSCS VGQEMQTFYA DISRWRSELE EQSVDSGSTS
DAIQLITYVQ QLKKKTKFCQ EKTEQFRAAQ RLLTQQRYQF PSSWLYSENI DGEWSALTDI
LERKDSAIQA QVANLQAKIK EEDEQVEKRT QDILNEWDKL KPVQGSQKPV EALATLNALE
TKLSKVKEDR ENMVKAKGAL EISEPIITNT HATRLDVAVE ELTDLKGVWS ALTPLYNSIE
ELKEKTWLSV QPRKLRQSLD ELLAQLKQLP AKYRSYDSYE YMKRLMHNYS KMNMVVVELK
SEALKERHWK HLMKELRVSW NLSDLTLGQI WDTDLLRYES AIKQVLLVAQ GELALEEFLK
QVREYWQSFE IDLVNYQSKT KLIRGWDDLF NKLKEHMNSL TAMKLSPYYK QFEEDSLAWE
EKLNKISALF DVWIDVQRRW VYLEGLFSAS ADISTLLPVE SSRFSSVSTE FLSLMKKVTA
SPRILDVVNM QGAQRVLERL ADILTKIQKA LGEYLERERS SFPRFYFVGD EDLLEIMGNS
KDISRIQKHL KKMFAGITSI DVESENTVVT AINSREGERV ELIRPVNLKE NPRINDWLRM
VEREMQHTLS YLLSQSLADF SKFDSAELEK YLNWMDQYPA QVVELTANIW WCMQIEKRLS
EGKIVEEVQV TVDKILSMLA DSVLCEQPPI RRKKIESLIT EFVHKRDICR SLVANNVSHA
NSFHWLKCMR FYYDSRSTSP LSCCTVKMAN AHFPYGFEYL GLQEKLVMTP LTDRCFLTMT
QALNSRLGGS PFGPAGTGKT ESVKALGHKL GRFVLVFNCD ETFDFQAMGR ILVGLCQVGA
WGCFDEFNRL EERMLSAVSQ QIQTIQEAVR AGGDMQVDLV GKTLSVNANM AIFITMNPGY
SGRSNLPDNL KQLFRSLAMT QPDRQLIAQV MLFSQGFRSA ERLANKIVPL FILCKEQLSD
QYHYDFGLRA LKYVLVSAGN IKREEIQRMI DNGESFGNPE CDVSSNLSEQ QILIQSVCET
LVPKLISEDI SLLFSLLSDV FPSIDYKPSP LTQLREEIAK VCDQLLLTQS STAGELGSTW
LEKVIQLNQI INLNHGLMLV GASGSGKTIA WKVLLKALER LEGVEGVAHV IDAKAMSKDA
LYGTLDPNTR EWTDGLFTHI IRKIIDNVRG ETSKRQWIVF DGDVDPEWVE NLNSVLDDNK
LLTLPNGERL AIPPNVRIIF EVSDLKYATL ATVSRCGMVW FSDEVVTYDM LSDHFLRMMK
HFRLDVEQPF DLMSLNTASV EGNNISPESE RVLAIQQKCV QFLAHHMSAD ALVPATLNYA
MSELDHIMEP TQQRLLSSFF SMMKYAVRQL IIYDNNHSDF PIADDQIEAY ILRAMLVNMV
WSFSGDGKWK SRQKLSDFVR QSCTLSLPPN ASLPIIDYEA SIMGEWVQWN SKVPQMEIET
HRVAAADIVV PTVDTIRHEM LLNTWLSEHK PLVLCGPPGS GKTMTLLSAL RSLQDMDVVN
VNFSSSTTPE LLMRTFDHYC EYRRTPNGVV LSPVQISRWL VIFCDEINLP APDKYGTQRV
ISFLRQLVEM NGFYRASDHT WVSLDRIQFV GACNPPTDPG RHPLSLRFLR HVPVVYVDYP
GSTSLIQIYG TFNRAMLRMA PAIRGLAEPL TSAMVDFYLQ SQEHFTQDDQ PHYIYSPREL
TRWVRAISEA ISPLDSVTAE ALVRLWAHEA LRLFQDRLVH AHEREWTDQL LNLTAEKFFS
SACNLTHALE RPLLLTKHYL PVSKEQLKEY VSARLKGFYE EELDVQLVLF DQMLDHVLRI
DRIYRQPQGH LLLIGVSGSG KTTLSRFVAW INGLSVFQFV RQFSKFQLKV HSKYTAADFD
EDMRSVLRRA GCRNEKMCFI MDESNMLDTG FLERLNTLLA NGEVPGLFDG DEYTTLMSQI
KEGAHRQGLM LDSPDELYKW FTAQVMRNLH IVFTMNPSGD GLRERASTSP ALFNRCVLNW
FGDWTDSALY QVGMELTNTL DMDKSDYQAP FAITAVCELV PSPMLYRHAV INSFVQVHNA
VRKLNEVEAK RGRRVMAITP RHFLDFIKHY INVFHEKRRD LEDEKLHLNV GLNKIKETEE
QVLELQKSLT LKSSELEAKK SAANAKLKEM LSDQQKAEKE KLASEQLQKE LAQSLVEIGK
KRTEVEKDLA QVEPAVEDAK QAVKSIRKAQ LVEVRSMAAP PHLVKLTLES ICLLLGENVG
TDWKAIRGVM VKDDFMPRIL GFDTDSITPE TLKAMEKYIQ NPDWDFDKVN RASSACGPMV
KWMKAQLLYS DMLRRVEPLR NELKRLEDDA KIKTEKGEEL KKTISQLEHS IAAYKEEYAQ
LIGQAETIKA DLATVKEKVG RSTQLLKSLG SERDRWHGSC DGFSQQMDSL IGDTLLSAAF
LAYSGYYDQH LRDMLFHRWI SFVEQAQIKH RSDLARVEYL SSVDERLEWN KNGLPVDELC
AENAIMLHRF NRYPLIIDPS GQAMKFLLKQ FSGKNMTKTS FLDNSFRKNL ESALRFGNAL
LVQDVESYDP ILNPVLNREV KRTGGRTLIT LGDQDIDLSP AFQIFLITRD ASVEFPPDVC
SRVTFVNFTI TQSSLEMQCL NQVLRSERPD VDEKRNDLLK LQGEFAVRLR QLEKALLAAL
NESKGKILDD DSVISTLEKL KTEAAEVARK AAETNKVMTE VETVSQLYIR LAQACSLIYS
MLQQLNEIHF LYQYSLDFLL EIFTAVLNTP HLSSITDYGQ RLQIITSNLF QMVYRRVSQG
MLHQDKILLA LLLMRIVLKG NSKEPSYQLE VDISKMFLYI VL
//
