ID A0A0N4ULX6_DRAME Unreviewed; 379 AA.
AC A0A0N4ULX6;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
GN ORFNames=DME_LOCUS2699 {ECO:0000313|EMBL:VDN52726.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000882301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000882301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN52726.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; UYYG01000075; VDN52726.1; -; Genomic_DNA.
DR STRING; 318479.A0A0N4ULX6; -.
DR WBParaSite; DME_0000882301-mRNA-1; DME_0000882301-mRNA-1; DME_0000882301.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02520; Glucosylceramide_synthase; 1.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..379
FT /note="ceramide glucosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041041047"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 379 AA; 43365 MW; 061CE92B4257FBA8 CRC64;
MLSAIWLCLL VKCHLHRNLI ASNEFPGVSI IKPLVGTDEN LFLNLESFFK LNYPMYELLF
CLHSDNDPAQ KVVEALMLKH PHIDAQIFIG GEDVGMNPKI NNMMPAYRAS KFPLILISDS
GIYMREDALM DMVIAMKEDV ALVTQMPFCM DRFGFGANLE QVYFGTSHAR IYLAANCLRI
TCSTGMSSLM RKNCLEEAGG MEKFSDFLAE DYFFGVAFKK RGWKITMSSL PALQNTANPD
PNKFHSRICR WIKLRFAMLP HTILLEPLQD CFVSGLLGCG SILILLPTYP TLAMYFFIFH
LIYWIVCDYI LIRIVQNGPL PFSFAQFLFV WLYREGSAFP TWCSALINPT VKWRSSAFRL
LWGGRIQEQS LPVTKWLIH
//
