ID   A0A0N4UNE8_DRAME        Unreviewed;      1334 AA.
AC   A0A0N4UNE8;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=G_PROTEIN_RECEP_F3_4 domain-containing protein {ECO:0000313|WBParaSite:DME_0000942801-mRNA-1};
GN   ORFNames=DME_LOCUS3132 {ECO:0000313|EMBL:VDN53159.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000942801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000942801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN53159.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UYYG01000107; VDN53159.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4UNE8; -.
DR   STRING; 318479.A0A0N4UNE8; -.
DR   WBParaSite; DME_0000942801-mRNA-1; DME_0000942801-mRNA-1; DME_0000942801.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   Gene3D; 3.40.50.2300; -; 4.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24060:SF172; CELF35-1; 1.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 2.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1334
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033231834"
FT   TRANSMEM        1024..1049
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1061..1081
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1093..1112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1133..1153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1183..1205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1029..1152
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   1334 AA;  151123 MW;  E6341FC1BD1B4051 CRC64;
     MEYIYKIALI FTFFFLNCGC IPNTSLCSIF DAFRIQPDNI KYEIGGAFPL HGKDCTELEA
     STVQDIVAIQ WALTYWNQNS NNSQAKIGLY AGDSCSRVKE ALFQTTRFLD SLGYLGPEEC
     ISETKRRRLS PILLGLLSPK DYESANAVAS SIKSLSIPVV TYSTSSAQAF INNGINNFIT
     TAPTLSVFIE VFLKLMKILK SDLVCIVDDG TQIQSISRLV HQIKSKKVFV SEIVSLDDPN
     FFDIISYSDS QIILSLINKH QLIDLLTKAN ALRRDKLWIA ILPDSDRLSP QEQSNIVMNG
     IKIQAIILQQ KQKEFFQFGE YFQRVIKDKY QSYFLLTAYV QKVHNCTTSR FENKIDCSKL
     DLNMIKSKYE QATSVEPAIR AAYGFAAVGA KLSNSKDKKI CEKLSSECTK RILFELESLI
     YEFNSEDVED LNEERLRFYR LNESILISSG IIIEGIELIN DDFYGPIIAK ARRQSRFVNN
     NLRVRKIRSI CPPYRSFCGK CHYTVQAKPN RYFLLTPKEY PVYLMGLFDF REGHSCELIG
     NFDISIPMAF YYTVSTFQQK YGENDLLRNL DLGVIFADSC TVARRAVETI LLGENHCFSF
     QQAERNITLV PGSIFGEKKS HLSAVNDVAN NAIEELFTLG ENVLLSFNSD RSNSIDKFTT
     MPSNKHQAIA LVKILKKFHW EYVTVVLSEQ DMTSKAAFRH FEEMATNRGI CIAAVVRIIG
     SNIPNTVSPS ATNVTLFFAT ALDTANFFAA RFRRDSYQSR IHIVLGNGHD FYLADPSNIA
     SFVGTLSIQP KDKIRDDFRQ WIESITPLTF PEPWYWDYVE NQWQCALSAA NRQRYGGNMC
     TGVELLDIPS LGRMTRSGYL SVMLEKYLFA VDSVYKKLCP EQKGICNEFY IKGKKQILNA
     LRKTQVEDAF DIYEFLPDIG GTFSYKNIGN WSFKNGLQFS ENYQYFDFLA NLHSSNKILS
     KTVVSLCVPP SCECRSSYKK RTEVLSDDSP SISGSYIRSQ PANSVTNRDY VSLSADLGYS
     NRRVWNYVLL TLITITLITA ISIVVLVCVK MYLRVVKGNQ SLGISLLIGV IILNISAYLF
     IMDPSDVICR LRMVFHSIGY TVCFGVMIAK ATQLKNAETL GFSTIGYISY WNYWLLLLFV
     IGVQIALSLR WLAQQYVLNI VLNGPQYHPV CAYSDLEFLT SQAYVDSIVV IELILCSIIL
     LGFLFGPKLY ILMSYETVVV DCETNTINGK GTLYENDLFE PVTNQDSKRN ISPVSSIYNY
     SVGTPSPATN RPRSDDQGPV FQTVVRKKTK RRSSSEYAPR IQPLFDQQLS SATLEIKVKS
     HKAPDSLRPT IKYG
//