ID A0A0N4UP00_DRAME Unreviewed; 2460 AA.
AC A0A0N4UP00;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Spectrin alpha chain {ECO:0000313|WBParaSite:DME_0000966601-mRNA-1};
GN ORFNames=DME_LOCUS10718 {ECO:0000313|EMBL:VDN60745.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000966601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000966601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN60745.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR EMBL; UYYG01001239; VDN60745.1; -; Genomic_DNA.
DR STRING; 318479.A0A0N4UP00; -.
DR WBParaSite; DME_0000966601-mRNA-1; DME_0000966601-mRNA-1; DME_0000966601.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR CDD; cd00176; SPEC; 11.
DR Gene3D; 1.20.58.60; -; 18.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035825; Alpha_Spectrin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 20.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 20.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 14.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1020..1079
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2310..2345
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2353..2388
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 954..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 344..403
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 767..794
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 916..943
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1196..1223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1263..1304
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1685..1755
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 956..975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2460 AA; 285518 MW; 1A35BA4CB8F2A123 CRC64;
MIESSTAPPE PVLEVPPPQE IKILETADDI QLLSDVGGIG QESSDIISPS EILVSLIVID
FDYQDFLFFK NRRSEVLGHY AQFKVYAKTK RDRLEDARQF QYFKRDADEL EIWILEKLQT
ASEESFRDPT NLQAKIQKHE AFEAEVHAHS NAIAQLDKTG SDMIQHDHFA SEIIRKRLDE
LHALWDQLFF KLKDKGIKLQ QALKLLQFIR QCDDVLYWIR DKEAFVTAED FGMDLEHVEV
LQRKFEEFLK ELGNHHYRIT EVNQAADKLI EEGHTEQNTI YNKREEVNEA WHRLNTLAAT
RREGLFGAHQ VQRFNRDIDE TLAWIGEKDA TLSTDDYGRD LNNVQALQRK HEGTERDLAA
LDAKMNSLAI EADRLAQVHP DRADAISAKM NEAKDQWAAL KRKAQARKDG LDRSYNLHRF
LADYRDLSSW INDMKAVISA DELAKDVAGA EALLESHQEH KGEIDAREDS FNQTAEAGQR
LLDEDSEQSD DVREKLGHLA KKKASLLSLW EERRILYEQC MDLQLFYRDT EQAETWMTKQ
EAFLANDDLG DSLDSVESLL KKHEDFEKSL AAQEEKINAL DEFATKLIQG QHYAADDVSR
RRALLLERRR HLMQRAAERR RQLENSYRLQ QFDRDCDELL SWIMEKLKTA KDDSYLDPTN
IRGKLQKHLN YEQELKANKN RLDEINTTGQ SLIEKNHYAA DHIRKRLGEV DGMWDELVDA
TAKKGAKLKE AGDQQQFNRN VEDVELWLSE LEGQVASEDF GKDLISVQNL QKKLGLLESD
YNAHQDRIDA IKQQAKTFYD SGHFDAPMIL RKQETLHSRY ENLLDPLNKR KNKLAESLKG
NQLFRDIDDE LAWIREKEQV AASTNRGRDL IGVQNLIKKQ QALIAEIANH EPQIDAVSAS
AEQMISQGHF LAPDIRDKLA QLRDNWRNLK AKAEKRRQEL DDSLQAHQYL ADANEAESSM
REKEPVVGST DYGKDEDSAE SLLKKHRALM SDLEAFKSTI DELRKQASQC RYQEQPGGQL
GRECVMALYD YTEKSPREVS IKKGDILTLL NSSNKDWWKV EVNDRQGFVP AAYVKKVEPG
AAQRQSQQVS SIGVKQNEIE DQYQKLLILG ETRRRKLEEA CKGYQLLREA NDLADWIRSR
EAVAAQQEIG SDLEQVEILQ KKFDDFKGDL KANEIRLQEM NQIATALTSV GQTETAVRIR
QQIDDLNARW RALEEQTEQR EQQLGSAHEV QRFHRDIDET KDWILEKDDA LDSEDFGRDL
RSVQALQRKH EGVERDLAAL GDKIKTLDEK ANRLRQTHPE AAEQIYDLQR ELNEQWNRLT
TKANNRKERL LDSYDYQRFL SDFRDLMQWI AAMNQLVSSD ELANDVTGAE ALLERHQEYR
TEIDSRAATF QAFEQFGNQL LNSHHYASDN IKQRLNDVNE ARRKLEDAWI HRRHVLDQCL
ELQLFNRDCE QADTWMSARE AFLNQEDTGD NVESLIKKHE DFDKAIASQQ EKISALRTFA
NQLINSDHYG KDAVADKRDQ ILQRWDRLKS ALIEKRSKLG ESQTLQQFSR DADEIENWIA
EKFQVAQEEN YRDPTHIQQK HQKQQAFEAE LAANADRIAT LISAGQNLID GSKCAGSEDA
VSQRLKALND QWEMLVKTTS EKSYRLKEAN RQKSFMAAVK DLEFWLGEIE GLLASEDYGK
DLASIENLLK KHQLLEADIA AHADRVAEMN TQADNLLENE QFDRPEINNR RKIINDRYEN
VKKMANLRRD NLNKAITVHQ FLRDIDDEES WIKEKKLLVS SDDYGRDLTG VQNLRKKHRR
LDNELASHEP QVFLVREKGL ELANMSNVCA SEIKDRMAAL EKSWDEIKNI TGKRHQKLNE
SEDFQIFIGK VEEEEAWMNE KQQILSSDNF GENMAGVQGL LKKHDAFEAD LVLHNQRVAQ
LIKDGQKLID AGNHHSPTIK ARCDQLRNRL DEITELARRR LQKLRDSSAY LQFIWKCDVV
ESWIAEKEQQ VRSDDFGRDL SSVQILLTKQ EAFDAGLNAF EHEGIQRISE LKDQLVNAQH
AQTPAIEKRY GNVIMRWQQL LGNSNARRQK LLKMQEQYKQ IEELYLTFAK KASAFNSWFE
NAEEDLTDPV RCNSLEEISA LREAHAEFHK SLSVAEEDFK QLQHLDKQIK SFNVGPNPYT
WFTMDALEET WRNLQKIIKE RELELQKEHR RQEDNDKLRR DFARQANAFH HWLTETRAAM
METSGTLEEQ LELLKRKVAI DVKNNRAQLK KIEDLGALLE EYLILDNRYT EHSTVGLAQA
WDQLDQLAMR MQHNLEQQIQ ARNQSGVTEE ALREFSMMFK HFDKEKCGRL DHQQFKSCLR
ALGYDLPMVD EGQPEPEFQR ILDIVDPNRD GYVTLQEYMA FMISKETENI QSSEEIESAF
RALSKEFRPY VTAEELYANL TPEQAEYCIK RMKPYTDAIS GRSVPGALDY EQFVHTLFQS
//
