ID   A0A0N4UP62_DRAME        Unreviewed;       446 AA.
AC   A0A0N4UP62;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Thiamine transporter 2 {ECO:0000313|WBParaSite:DME_0000973101-mRNA-1};
GN   ORFNames=DME_LOCUS3347 {ECO:0000313|EMBL:VDN53374.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000973101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000973101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN53374.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000256|ARBA:ARBA00005773}.
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DR   EMBL; UYYG01000125; VDN53374.1; -; Genomic_DNA.
DR   WBParaSite; DME_0000973101-mRNA-1; DME_0000973101-mRNA-1; DME_0000973101.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00806; rfc; 1.
DR   PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR   PANTHER; PTHR10686:SF18; FOLATE-LIKE TRANSPORTER 3; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        87..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        117..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   446 AA;  51589 MW;  36932A805F2D7C22 CRC64;
     MVRSAKEEAE FFSRIILKIT RKSFTVAISN FFRFTLFLNM KWWLQVILLI LYAFWKDFKP
     GEPFLFKYHV IFLNLTEQQL NGEIYPYWTY SYLIAMIPIF LLTDLLLYKP VLMCENIGYI
     VFRVSLVFLS SVLSQQIGHV FYGIATASEI AFYSYIYASS DKRDYQRITS WTRAASMSGR
     TVGYLMSQLI IITKLGTYLT INQISLASPI IALIIASCFP KVHWKTLIDR IEKTPGTIDD
     NNLKLPRTYL AYCRYRIEKM YCNAKTNYSI GFVSKWSLWW AMTTCMSLQV SAYAQTLWGE
     VQEEERTLNG FAEATYTASA TTAILIMHAT RIDWDRWGEI ALVIISTVDC ALLLLFSRTN
     SIYVMYGCYI GYRTLYQVMI TIAQWNLARK MVCCSYGLLF GLNTFIALIL QTILTLVIVD
     KRGLGLNARI QIRYSSFSTF VEDYAA
//