ID A0A0N4UVT5_ENTVE Unreviewed; 475 AA.
AC A0A0N4UVT5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN ORFNames=EVEC_LOCUS1276 {ECO:0000313|EMBL:VDD86133.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000156801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000156801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD86133.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UXUI01007192; VDD86133.1; -; Genomic_DNA.
DR STRING; 51028.A0A0N4UVT5; -.
DR WBParaSite; EVEC_0000156801-mRNA-1; EVEC_0000156801-mRNA-1; EVEC_0000156801.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131}.
FT DOMAIN 313..472
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
SQ SEQUENCE 475 AA; 53486 MW; 3D6A5728FC8079AA CRC64;
MVKDEVKESP PLKALVIADS FDRRFLPVLG NSLSWVMKTV FFWSIFSFWD GYFQSLTLVS
CQNCMSVGDV IREVDGRSLI SSEFLLISNP ASFCSFDLRP QIKAFFERRK DKNNVMTLLY
AEREGLNPVI CLEKKSNKLA AFLGESVVRN DIQDTGLALC SPVICNQFSD NFDFQRRDDV
IREILVHEGV LCQNIHVDVL PSNTAAFTVN DYEGLLHANK LILQRWLYPL IPSRVGDGRF
ITLRNNIYLA SSDNEITHQD LTNCEGAHVQ SSIIGNNVSI GRNVKVLESC VGDNVVIEEG
ARIGPKSIIA KNVGFDMANL ILVKDSMERT ASEEEFSNDL VESLILEINC SKLACNISTE
DVARRVFSSF LGLPQNENFS KVKKVGFCYV MLYLTFVYRL KDVTGFQEYV ALSGRLKPVA
PNIVHLFYEL GIFEEEAILE WYNTVADDAP VKKLVAPIID WLNTAEEDDS SDDSE
//
