ID A0A0N4V250_ENTVE Unreviewed; 2173 AA.
AC A0A0N4V250;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=VWFA domain-containing protein {ECO:0000313|WBParaSite:EVEC_0000406201-mRNA-1};
GN ORFNames=EVEC_LOCUS3770 {ECO:0000313|EMBL:VDD88627.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000406201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000406201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD88627.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; UXUI01007680; VDD88627.1; -; Genomic_DNA.
DR STRING; 51028.A0A0N4V250; -.
DR WBParaSite; EVEC_0000406201-mRNA-1; EVEC_0000406201-mRNA-1; EVEC_0000406201.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR006582; MD_domain.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR47324; PROTEIN IRG-7-RELATED; 1.
DR PANTHER; PTHR47324:SF2; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00604; MD; 3.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2173
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041042973"
FT DOMAIN 317..350
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 781..818
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1134..1273
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1979..2132
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DISULFID 340..349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 808..817
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2173 AA; 242475 MW; F80B606E557CD61E CRC64;
MEMALAALLP LLFTSVFCVS ASNEAVKAGN SCPEGWTGNN CDAPICYEQK IIERHEGGSY
GDYLFWEQSS RCSGEFYFYV DEFVQNITLY VEGGENFFGE VRKNEKRVQA HGTPPVVSPD
IHVSEFDEIA SFYGYGVYTI VVQSDGTESC TIYVRSATSL MIDGGFVQDR RDDSAQYVVP
QINQGVGRYP IVNNNSYFAF QYPVALSHPG RANFVYINSG SGYGSRIAVK DRYGCGASYI
SNAVQCEEDL SLTYHLKVEG VDTKGNTWQR VYIYMCETYA TPSPPPTEPP PEQCLNGGIL
VNAGTAQQEC YCGNDYEGRM CETKRCFNNG QVGKYGRCTC AVGYTGESCE HVFCQNPTEG
YGDSKYKAIV FIVRSGLSMA GHIEEIAGAA RTIASYYQSD SYIQRWVLVT VFNGMVDVQS
TTRADEFVNA IRAIKIEQDT ICNDAIYTAI STAIDTPAVQ MYKRSMFFIF TDGMPDDNTE
ERLTLLHQLS FFRGQMFFML ANSVSGRCNI DTASEGYRGL RYLAQFSFGQ VTYVDLEDLG
SASLLTLLFN LKMQWATVVL AITAHKADHI FSNDLMDSCK RAPKYQSFFV DHSLRNVFIS
ATGSNLNLYL TDPSRNRTEA TLFYSSSDHL YVWQIENLMY GGYLMELESQ SYNPCSLRVF
GYGDTSLWVG ISTGLAEDAT VTQPIYQQTS HMVARINDVN YPDPTQILAE ATIWTNEGTS
DKRTVLYASG GIYRDSCNFN LYFGEWECAY PNEFFYMNVY VTASNGAVIQ RSYTGFCSIV
ETTQTPPGQC MNGGVETTLS NGTQTCICPA HYTGKKCEKI QCLNLGTAIG NKCECVSGFT
GQFCETSVCH QRNEDFDFGP NKRSLTLIIQ DSISTRTSMR SIKNQLPSLV QDLTHQHAEW
ISTYQLYRFN DSTFTKVAST PNANEFLQGM DALYSANLAA SDPSCRDLRV LPGLLGVLMN
HQLTLNGVVY LFINGYMKLD VTTSEVEAVY ELLERTKVMF NVVLMSGSPC GRDLSENETL
VLMNFAGYTG GQFIMVMPPR AGSVIRSTPT LYRANYIYET YKENCTEPEP IYFPIDSQTQ
SFTAYVVGDM EDNAIKYYRP DGSKKEPFTI WKDLGMGSRM DQIIRECDDG WELSGNRCWH
FGIVPRTWSE ARDLCHNNNA VLITIFNQAE QDYIDSLARG EPYWTGLKYD STSSAYVWDT
TEGTPLTVFI SKDDFKLSYN KKTRHMALSS TGYNNFPGGN VPAFNLTTQC VFDKHPVGWS
LAACSERRSY VCVKHACSKN ICVSKYLEKN VVSSTSVANS RISLTSAEET NNADYEPDFQ
DLGDLLARGI WKMTVQTISG ACSVQIYSQS AIQMFMEFSS DIHSDFGSQQ PYVQASDNRI
IAHVTKQTST SAGLTGSLQY AHLYKISSNI TIVQAQTFSK RDMATCAFEY LSTSFKCPSE
HFLSLNTGID RFGYLYQRIQ PISCFKGPVP GDCVNGVYNQ GHCVCDPYYE GELCETPICQ
KGTLDSLREN CKCFAGYAGV VCDIPVCNRG TSQNMPSINN RTFVLLLDGS KTGRMKNIAS
SLEDLLTSVF DESNEPEYRG WFTHYTGVVF RDSSVGEQSV SEVIESDDST DFVKKMLAER
DKSYTPSGES RSVMAAIVRA MQSTYVQPRS YVFVLTGADA EDYERKTAAI EALARTHCYV
EFLIVGDEEA PGGGKNYTKP QLVAYYDIVR ETSGQLYQVQ DNEGNVDVFK TFWRSLFSTY
YDTFFVTTVQ KQDCSSGIDE YVQLGYNAST LIIDAVGSGQ VSIFDPQNRQ VNNINSIKGS
RTNRVNTVSV NMTGLWKITL PEYKGFCRLQ VKGKSNIEIF IGYVHDGTDG GLHSRDVDYR
PLTDGVNAVV AKSDVAKINF VQIFSLDERK LLWSSPMIAR RSCTYQYVSS RTFTCTEPSL
SVAVEGEDDR GYPIRRMIHT HCVGNFATTA APGTTATLLT TTPVVTLKPL QCDDNAKFDI
ILMFDGSDGF NANDFEDVVK AFESVPEKMN ISQNGIRFAI GTYAESAEIF STFENTDVTE
FHNTLQRLVS FGHEGVTANN ISDIFTKIEN LNFRDSVPRV LVMFSSLRLD VGLGEAYPDP
KQQAEEFRAK GKILPIGYGK YVDADLLKNL GNNCAKFAGD MLEMKALLPW VTSSLCRFVI
GYLKKLPLLW LTG
//
