ID   A0A0N4V409_ENTVE        Unreviewed;       554 AA.
AC   A0A0N4V409;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00018388, ECO:0000256|RuleBase:RU000612};
DE            EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
GN   ORFNames=EVEC_LOCUS4526 {ECO:0000313|EMBL:VDD89775.1};
OS   Enterobius vermicularis (Human pinworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX   NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000481801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EVEC_0000481801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDD89775.1, ECO:0000313|Proteomes:UP000274131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC         EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC         ECO:0000256|RuleBase:RU000612};
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 2/4.
CC       {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC   -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC       ECO:0000256|RuleBase:RU000612}.
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DR   EMBL; UXUI01007884; VDD89775.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4V409; -.
DR   STRING; 51028.A0A0N4V409; -.
DR   WBParaSite; EVEC_0000481801-mRNA-1; EVEC_0000481801-mRNA-1; EVEC_0000481801.
DR   UniPathway; UPA00109; UER00181.
DR   Proteomes; UP000038041; Unplaced.
DR   Proteomes; UP000274131; Unassembled WGS sequence.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05015; SIS_PGI_1; 1.
DR   CDD; cd05016; SIS_PGI_2; 1.
DR   Gene3D; 1.10.1390.10; -; 1.
DR   HAMAP; MF_00473; G6P_isomerase; 1.
DR   InterPro; IPR001672; G6P_Isomerase.
DR   InterPro; IPR023096; G6P_Isomerase_C.
DR   InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR035476; SIS_PGI_1.
DR   InterPro; IPR035482; SIS_PGI_2.
DR   PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR   Pfam; PF00342; PGI; 1.
DR   PRINTS; PR00662; G6PISOMERASE.
DR   SUPFAM; SSF53697; SIS domain; 1.
DR   PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR   PROSITE; PS00174; P_GLUCOSE_ISOMERASE_2; 1.
DR   PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE   3: Inferred from homology;
KW   Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW   ECO:0000256|RuleBase:RU000612};
KW   Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274131}.
SQ   SEQUENCE   554 AA;  62211 MW;  FD027745656EC87B CRC64;
     MSLNADSAFQ DLKKYFDEHG KKLKLVELFK NDPQRFEKLS LKLDVPNGQI LFDYSKNLVD
     EELMAKLFAL ARSRHVEDMR KAMFTGEKIN FTEDRAVLHT ALRNVKNRPI TLGSQNVTED
     VNKVLAHMKQ FCDQVIGGEW KGYTGEKITD VVNIGIGGSD LGPLMVTEAL RHYQVGPKVH
     FVSNIDGTHL HEVLKRVRPE TTIFIIASKT FTTQETITNA ESAKEWFLAA AKKPEAVAKH
     FVALSTNAPK VKAFGIDEAN MFAFWDWVGG RYSLWSAIGL SIAVHIGFEN FHSLLEGANA
     ADEHFVESPL EKNIPVIMGL LGILYINLYN AETHALLPYD QYMHRFAAYF QQGDMESNGK
     FVTRDGVHVD YSTGPIVWGE PGTNGQHAFY HSSCFFLGTR LIPADFIAPV NSLNPIRNNL
     HHNILLSNFL AQTEALMKGK TEEEAKKELM ASGMQEEQMK KIFPHKMFEG NRPTSSFLLT
     KITPSTLGAL IALYEHKIFV QGVIWKINSY DQFGVELGKQ LASKILPEIT TTTPVSTHDA
     STNGLMNYIK SHRS
//