ID A0A0N4V470_ENTVE Unreviewed; 1294 AA.
AC A0A0N4V470;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=SSD domain-containing protein {ECO:0000313|WBParaSite:EVEC_0000488301-mRNA-1};
GN ORFNames=EVEC_LOCUS4591 {ECO:0000313|EMBL:VDD89840.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000488301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000488301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD89840.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; UXUI01007900; VDD89840.1; -; Genomic_DNA.
DR STRING; 51028.A0A0N4V470; -.
DR WBParaSite; EVEC_0000488301-mRNA-1; EVEC_0000488301-mRNA-1; EVEC_0000488301.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF1; PROTEIN PATCHED; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1088..1108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1115..1136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1142..1170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1182..1202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1208..1231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 582..743
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1294 AA; 144456 MW; 9946E7419DB3F4EB CRC64;
MLMLIEPPGT KRGTSPTSRP QNPLLGLGEI FLTEEFPEII AFCRLQKLDS FLVGKSNSGD
FSERWKQEFS ERPSWCDADM TLQQIKRGKA RGNRAALYSR SFIQKILYSL GSFVQRHSFL
VIFIVALLFG ICCYGLQFVR IETDIVKLWV AKGGRLDEEL NFLSVVEEKS VIKGSVQRES
GLGGGFQVII QVPREEGQNI LNQNDLLEHV ALMEEIAKYS VTSGGVNWTL SDICFKPPSP
EIDDNSLAKS FAAVVDRIVP CVLITPIDCF WEGSKAIGPH PPVESSTLGF AEYFFPALSG
LRTLSWGNID PEALVKQIAD IAPIGNLHSF FYRAGIGKGY LDRWCIDPLD PDCPESSPNH
FNFCKLIPRF LEYASRSGFE VPEDPEYMKW REKSSDDFLD FTILLSVLLI DYFLLNFLCK
KYARPFANWM RKNVDRWQMF LNKFPTLPDY GKVMDGGCRG FAKEVMSWPE DLIIGGVKKT
QGHLSAAEAL QSVILVASAN DVYLRFKDAT KTHLKPGLNL TSWSYGEAEK VITAWQRKFT
QSLYDHKLND ELDPVTGKKH RRIHPLASTS IADMLEEFCQ FNYTIILVGY LLMLLYAIHS
QMKLHNCKLA TDSCMGLAFA GVLTVTFASI SGLGFATWCG IEFNAATTQI VPFLTLGIGV
DNIFLLLHSY HAVTGNMKRN EIGMLMKETG MSVVMTSFNN ILSFLAGTVL PIPALRSFCA
QSSILLTFNL IAILTIYPAV ISIDLRRQKN SRRDVFCCSG DLQGKYSNPK KTVGEPVPSG
DDIEEDVKSW TLRAFLHNYY VPFLKNKVFI LVICFCMFCG GIIGVYRASY GLELSDVLPE
NTAPAAFLKA RDKYFSFYPM FAVLKGPDID YPNVQNKIEN YRNRIGKSSK YVVKVEDEPS
EKYWLALMRS WLKELQIKLD AAIARNKFDL RTGDVINETV ERLTLEENIA YRLICSYGSN
FNCSGRLGKV RFVDPSGTIN ADGFYNYLTA WYNLDSMMYH VSQASFVPPP PRWSVEWKTA
EIVPPAQPIA YSQIPFYLTG LTDTPAIVGM IKEIRAVCER FAAEGLPNFP SGVAFTFWEQ
YMHLSSNLMR AIGVIALSVF CVISFILLNP WAAAIIVGIL LLMTVELAGF LGVAGIKMNP
VSAVTIITAV GIGVEFTAHV VLAFLTSLGT RNDRMGACID RVFVPVIHGA LSTLLGIVML
AFSEFEFVIK YFFVVMSVLI AIGVINGLAL LPVLLSLIGP SCEVTPVNGG ARLSPPPRAP
LRKKRRRDIT EAQTHRRNIS DDSNTATLGP ESVS
//
