ID A0A0N4V4B5_ENTVE Unreviewed; 551 AA.
AC A0A0N4V4B5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN ORFNames=EVEC_LOCUS4645 {ECO:0000313|EMBL:VDD89894.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000496101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000496101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD89894.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR EMBL; UXUI01007916; VDD89894.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4V4B5; -.
DR STRING; 51028.A0A0N4V4B5; -.
DR WBParaSite; EVEC_0000496101-mRNA-1; EVEC_0000496101-mRNA-1; EVEC_0000496101.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131}.
FT DOMAIN 33..144
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 166..504
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 335
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 551 AA; 63781 MW; 3A8C96201DE745E8 CRC64;
MIFLLLFLLG AAEARKQYVS VWPDVTIKTK GEIWPLPQFF EKTNKTWRLD PNNLVITEST
HCEIITEAIK RYREIFCKHL NIADDDPQTE TLKSLEIILS QCSSDVPQSD MDESYKINIT
SENAVIKAAN VWGALRGLES FSQLIHSNEK SECQINGAIV RDFPRFQHRG VLLDTSRSST
QILLISLLNL KHFLSLNALK ATIELMAQNK FNVFHWHIVD EQSFPYDSKV LPLLKKGAFT
PRHVYTIEDV KDIIEYARLR GIRVVPEFDT PGHARSWGFG YPDLLSRCFY DDGKEDFYRC
LVDPTQQDTW DIMLSLFQEV FEVFPEEYVH LGGDEAEFWT SHCWKNNENI TNFMKVLELN
DTRQLQAWYF DHLLAILRLS KTGRQKTFLV WQEAVETNVQ VEGLIGHVWK GSSHEQYSNY
LKSVTSKGYR AIFSSCWYLD RISTSVEWRG YYSCDPQDFN GTAEEKKLVI GGEAALWGEW
VDDSNVVSRL WPRASAVAER LWSDQNSTSD VNAAWPRLYE MQCRMKARGY PAQPVNGPDY
CEFEYESNLP V
//
