ID A0A0N4VCF1_ENTVE Unreviewed; 1881 AA.
AC A0A0N4VCF1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=EVEC_LOCUS7729 {ECO:0000313|EMBL:VDD92978.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000824501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000824501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD92978.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR EMBL; UXUI01009064; VDD92978.1; -; Genomic_DNA.
DR STRING; 51028.A0A0N4VCF1; -.
DR WBParaSite; EVEC_0000824501-mRNA-1; EVEC_0000824501-mRNA-1; EVEC_0000824501.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF604; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1372..1399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1269..1367
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1447..1728
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1752..1805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1482
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1881 AA; 208736 MW; FC20F600C051F457 CRC64;
MNIGTEEKPT LLRSPDDTPV VHMDVDHMQE KLYAVLKKKG ILRCDLNNCN NSTIMTTNGL
NYVEYISLDP YNGYIYCVVH SGDIFVTPLF PYNASDVVVS PLTEKLAGVS GAFALEVDYE
NMQLTVATKN GTLFGMNLVN RSLTDLRSNY EVNGRYSGIK KLHFMKNRMF WTVPSCGVLP
LLDCLYSEEW DQENENVHLN QYLFAGRVVD FTFMRDRSLP LSVLPPDGIG LITSSNLAVI
TWKPPPLLPF QANEYEWRNV YYQYGLMSES EEQSNAKLAS SNRTSQILPI VPGLQYHASV
QACICSVCSA LSSAINSAFE SDSDPPFVMV NRKDGNLTSS IYRYSEVEGK TRFLETVTTR
FLTILPRFAL LVMASDYVIT SYRLSGSFEQ VLYSCDSLGS CGSVVGLGGD DETGDVFFLI
QNANSTISLF GFNQDMRKPY FISSSVDFPP IRQLLVAKEK LAFVTESNEI GVCDKKLGSL
NLNLIAEKVV LVHDENVTES HTITFTSSRL NVSSKRDRLS WEIASDLAGE KIIFKVNNVF
VKVAVFKDHF GGDRFVNYSL QPEFYLSPFI LGSWASKQVY DIKVDAINAW TIVSVNQTGL
IAPTKPPTTP QNLRVFATQQ KTVDGARALI DLFWDEPSVW NGEKSGYVVN CTVDGEERWS
TEILPVERTY SFNVKSGRVS CVVGARTELT LVTFSQPITI DSSDLRPLIR VFAVDSSNNL
VQVCNSSFSS NNLAKRQASS SAIAQQAIAY IGNNLYALRN DADIVQPYLL RLDSNNVEYV
IQKVSLAGNV AEVDAIISDW VANRLLFISG GNLLQLFLDV IENSVPFSSR ISTAYLLTKN
GSLFALFLNK KVEENLALRF ECLKTETVTA MVSNFVWNSA ALDSIVVLTW NGLSRLNFAS
STCEKIDIDD SIFGEKKLKA VLSFAVFGAR YLFTTATGVI EYDENTKNSK PIEAISLPPT
QYEIRFKRKD SDKITSTLTI ATTTHIESGV LDKETDYEVS VAFRNRYTSL VESSVTQLFI
TGYGYPTAPM EPAAVAIAPD AVVVFWKLPA KANAPLSELR YRISHSSELL SVPAAIGALQ
ADDSVSGGYA NSLTDVVSCV ANPCSAKLLH LRPATDYKFW VRAIHQSHLE SQYEDPEAIS
GEVAVHTKDT PGTVKPENIT STSVTLHWIS LEPESSPARI SIEYRVAEDK SAVSHSKNNS
VIKWKSPADA SFEWSHPATI VIERLRSATV YEYRYAADYK ESYSYGGRMI SVPGRYFHTT
QQIKTKPGTP SAPASLELIY DEEGFFVRWT APASNGGSDI VSYALEYRPS EDSEWEIAER
GLSFNDSEWR PLQSTSFGSN VEFRIRAANS EGFGDYAYSK PHQPNGSHSF PYSLWAVAAC
MVIASLFAAC VLVALLVYYR EHGKKLKKMK RLQIGLRQMN NLDTPFEIPA DLSCDLKCVP
RVKKSCINVK SILGTGSFGE VFEGVVCGLP HAPEKSVLVA IKALRKDCSQ LDRKKFLQEA
ITMHNFDHPN IVRLLGISID SEPLYLLMEL MEAGDLLTFL KSSRPTEVLP SQLSLSELIA
MMVDVGRGAT YLEANRFVHR DLAARNCLIS SRLSPRTTKI ADFGLARTMH KGEYCRLNGE
ELLPLRWLAP EIINGGSDGA FTSKTDVWSF GVLLWEIITL GQQPYAGKDQ FQVRSLIGEG
VTLEKPAACP DEIFAVIKRA WVFNPDDRPS FSELLPELEN LQESSHYLDE KPYPCSLTPY
ALTLTFESSI DSNASGSGSA DRSASIRFDK SDNHSTKKQG RPSVLRSLRK EQSKSPSLND
ALPANNMEFP EQAVLSSDTA ATYLDENTLD KSCLSSQLGT KEAFKNTQLN CLFAHSASSA
DTQSFNDSNS SYYRTARVSR V
//
