ID   A0A0N4VCT0_ENTVE        Unreviewed;      1016 AA.
AC   A0A0N4VCT0;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE            EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE   AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN   ORFNames=EVEC_LOCUS7870 {ECO:0000313|EMBL:VDD93119.1};
OS   Enterobius vermicularis (Human pinworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX   NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000838601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EVEC_0000838601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDD93119.1, ECO:0000313|Proteomes:UP000274131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; UXUI01009136; VDD93119.1; -; Genomic_DNA.
DR   STRING; 51028.A0A0N4VCT0; -.
DR   WBParaSite; EVEC_0000838601-mRNA-1; EVEC_0000838601-mRNA-1; EVEC_0000838601.
DR   Proteomes; UP000038041; Unplaced.
DR   Proteomes; UP000274131; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 3.30.230.90; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR002301; Ile-tRNA-ligase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00392; ileS; 1.
DR   PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274131}.
FT   DOMAIN          213..820
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
SQ   SEQUENCE   1016 AA;  116221 MW;  FB1FC6A13046E38B CRC64;
     MVQPVSYPSF LDLSFEYRGC YTHFTVTKFG NRDFVAVSNL GRFGQLVEVI FPHRLIADLL
     FEEHNFEYDT RTLLGAPVVN VRLNQHLLRI ILTCCLTVLS EFLLNTTDVE MLFSPLVLRN
     WTWIMPIKLS KHWRNILLKS RKYNPSEGSV RHLCTSCALN SAKAQKERSK KGIFLPETAF
     KVHIKTVERS GLDAEIASVG GFNSFYQWQL NDSSREGLPL FVLMDGPPYA NGDVHIGHAV
     NKILKDFVLR SRVYAGNRVQ FIPGWDCHGL PIELKISRDA EEALSPIEIR KRARKVAERS
     MNAQKASFKR WGVMADWDNP YYTMHPSYVA KQLKFFAKFY GKGLVYRAYK PVYWSPSSLT
     ALAESELEYN HNHESTAVYF RFEVINGHSL VQHLATDKRP IKLFAVIWTT VPWTLPLNDA
     IAFKPGTEYA LLELVPPFRE KTRCVYLIAK NLVEAFKKKM NQSWQMLGVV KDDCLEGLWY
     HCCMFVDIAR PFVSSKHVTT DTGTGLVHVS YAHGFQDYEI SVKRGDKVYC YVNEFGKYSR
     QLGYGLEDKF VLGEGQDEVL KMLKKHVLLA YPYVHSYPYD WRTKKPVIIR SSAQWFIDTT
     TLAEEAVKLI ENEEIEVGTP FTDMRNTLIQ VLQGRSSWCI SRQRCWGVPI PALFKEDKSV
     LMSQRFVEHV ADKIEREGSD SWWSSDVQSL LEDTFAKEFD LKGNERIQKG TDVMDVWFDS
     GLVWGCGRYE HLPADLIVEG NDQFRGWFQS LVLTSLALEN AIPFKKILVH GFAVDGEGKK
     MSKSVGNVVL PHTVTDGSLH SKALGADGLR LWVALHGSSG EARLSSEIAQ EIDRTLIAIR
     SSFRFLLGSL KGIGEKRENL SPYFIDQVSV VISNGNQLHF LAIILILQYI LQETNNFTQK
     CLTNYMKFKF RSVANDFIQF LQRPLSANYI GIELSCCKDD MEKLRKLQKD DRSFSSELVE
     ALGVSTVLLK GQEATDFSLR MEHSPLLFCN RCRKHRRVEG EEHCSPCTKA LAEYEL
//