ID A0A0N4VE10_ENTVE Unreviewed; 566 AA.
AC A0A0N4VE10;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN ORFNames=EVEC_LOCUS8344 {ECO:0000313|EMBL:VDD93593.1};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0000889201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0000889201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDD93593.1, ECO:0000313|Proteomes:UP000274131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UXUI01009379; VDD93593.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4VE10; -.
DR STRING; 51028.A0A0N4VE10; -.
DR ESTHER; entve-a0a0n4ve10; ACHE.
DR WBParaSite; EVEC_0000889201-mRNA-1; EVEC_0000889201-mRNA-1; EVEC_0000889201.
DR Proteomes; UP000038041; Unplaced.
DR Proteomes; UP000274131; Unassembled WGS sequence.
DR GO; GO:0003990; F:acetylcholinesterase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR000997; Cholinesterase.
DR PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR PANTHER; PTHR43918:SF9; CARBOXYLIC ESTER HYDROLASE; 1.
DR Pfam; PF00135; COesterase; 1.
DR PRINTS; PR00878; CHOLNESTRASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000274131};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW Signal {ECO:0000256|RuleBase:RU361235}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT CHAIN 25..566
FT /note="Carboxylic ester hydrolase"
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT /id="PRO_5033761790"
FT DOMAIN 35..535
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT ACT_SITE 228
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 355
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 472
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
SQ SEQUENCE 566 AA; 64825 MW; 5E7FB06DA9EF29A9 CRC64;
MGKNISFKAF PLPISLIGFY LSLADHSLHD GERYTLVSTR LGKLRGLESQ ILGQRVQSFL
GIPFAEPPIG DNRFKPPIVK KPWNDVLDAV HLSPACYQGR DNYNTSFWGS EMWNANTEVK
EDCLYLNMWK PAKHNHNLKV MVWIFGGGFY SGSPSLLLYD GKALAIKADA IIININYRLG
PFGYLYFDHE DAPGNVGMLD QQLALTWIKK HVSAFGGDPS QITLFGESAG ASSIVAHMIA
PGSRGLFRNG ILQSGSLDNN WAMVSPTEAM NRSRAYARRL KCEKNDVVET IKCMRAAPAA
NMIERQWDGL GFLDFPVAIV SRDRNFFKHH DAFTALRIGD YSHDVNIMIG INHDEGNFWN
IYNLPEYFDT ATQPLLDYEQ FKDCSETAFG KLPSAFRRAA MWTYNQNCSQ ICTKSKVYAD
MINQMVGDFY FTCDSLWFAD EYKRIGSGKI YIYYFDQPSS ANPWPKWTGV MHGYEVEFVF
GVPLFNKTAG YTTRELHFSE KIIEYWKSFA ETGATKRPTE QWPEYRETGK WMYLKGGSLI
RPIEKRKHDE CEVWRQAKDW QHFEYC
//
