ID A0A0N4VI05_ENTVE Unreviewed; 1134 AA.
AC A0A0N4VI05;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Enterobius vermicularis (Human pinworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Oxyuridomorpha; Oxyuroidea; Oxyuridae; Enterobius.
OX NCBI_TaxID=51028 {ECO:0000313|Proteomes:UP000038041, ECO:0000313|WBParaSite:EVEC_0001045601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:EVEC_0001045601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A0N4VI05; -.
DR WBParaSite; EVEC_0001045601-mRNA-1; EVEC_0001045601-mRNA-1; EVEC_0001045601.
DR Proteomes; UP000038041; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00064; FU; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR SMART; SM00261; FU; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1134
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005887572"
FT TRANSMEM 837..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..154
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT DOMAIN 170..328
FT /note="Furin-like cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF00757"
FT DOMAIN 399..489
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT DOMAIN 534..637
FT /note="Growth factor receptor"
FT /evidence="ECO:0000259|Pfam:PF14843"
FT REGION 996..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1134 AA; 127877 MW; 5DC7974C6E7AC1F1 CRC64;
LSTILLLGTI FTDCVGSIDG VTRAGYSDNI DILRKQYSGC TIVFGNVVIA HLQQKAIGNQ
TMEEMEKKLD FLNHIEQITG SLIIFATHLK SISFKRLKII WGDELHDGMA MLIEGNEELR
HLKLPSLRSV ERGNITLNSN PYLCYLEKKV SFHEIVGEGA SERIWRKNES TLCSKESEPE
CDRKCGQYCW GPGAENCQII YRQNCTDCHS GMCHFDNPSL PICCDDACAA GCTGQGSDHC
VACKRLSQDG QCVERCNGLT SYDIVKMMTV PHEKPRYTHN RFCVPECPPT TIIENENCVH
RCSKGYSYDA DSRPYVCKPC ENGICPKCTF ERLSCLLEEP LDSRNIERLK DCIIIEGYIF
LSPYAFVEHL YIPPDLSQLT FEKSSDMDRF DFMNTTVPAI KEEQLEILST VRMVTQYVEI
SLFDYSPTNL SFLRNLETIV GRKQRARQSL KIFSNSNLKY LGLKSLKKIL GGRVFITDNK
ALCYANTQSR TWDDIIEEVP EAGHRKFRIE RNRNPSICGN AVIYICYYLQ GRRCSDSCDE
DYGCWGPGSD QCVKCKYYYD GEQCLYSCSP IGNYVDGKNC LRCDEECVKC HGPSNEDCDK
CKHVSLQRGL RKQCLRECPN THYENNGTCV PCHPACYAYG PMFFSCTGGS DIAGLGGCNK
CEYGVELDGS IKCLSSENNS YSVCKENHLD NYFVHLETTD KIASYKCNKC PDECFSCTGF
GTDTAKHECV CAAYVTHSPG NRSYCTAKCE TGSYLIKEKT ANNTGHCQIC HELCDHSYGC
VGNKPSECER CKFAAVEKDG IQTCLDECPL GLHKYDDVNN VCHDIDPAAV VRRKKRIAAF
SFVLCVVFAV VIAAVFGVNC WKYRNRYKKE LQLNPPALPE YKPMDPDDKP NMNQLRLISS
EQLTKTSRPL GKGAFGIVYA VSWLENPDSR PTFVVLKTYF DSFCRVPNRY LVLKKRNPPL
PMESMNNENQ RDLINEMMQD NDFMDPLTYF DEHDGPTTES TIIPPTPTTP AWSSNNETSG
NSCNAILMSC QGRRLTNSDS TRYQSDPVHG DGSNIELSTD EGNYLVPNTK QSAVLYTPVV
VHENSETDLL SPTHYYNENG TPEYYNELKP ADDKIPMIRS LANRDYFAEA ETAL
//
