ID   A0A0N4W3M7_HAEPC        Unreviewed;       351 AA.
AC   A0A0N4W3M7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=P53 domain-containing protein {ECO:0000313|WBParaSite:HPLM_0000443101-mRNA-1};
GN   ORFNames=HPLM_LOCUS4423 {ECO:0000313|EMBL:VDO23203.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000443101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0000443101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO23203.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO23203.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602117-1};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR602117-1};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the p53 family. {ECO:0000256|ARBA:ARBA00006167}.
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DR   EMBL; UZAF01016209; VDO23203.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4W3M7; -.
DR   STRING; 6290.A0A0N4W3M7; -.
DR   WBParaSite; HPLM_0000443101-mRNA-1; HPLM_0000443101-mRNA-1; HPLM_0000443101.
DR   OMA; TEERYAN; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.720; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR   InterPro; IPR011615; p53_DNA-bd.
DR   InterPro; IPR002117; p53_tumour_suppressor.
DR   PANTHER; PTHR11447; CELLULAR TUMOR ANTIGEN P53; 1.
DR   PANTHER; PTHR11447:SF16; P53 PROTEIN LONG FORM VARIANT 1; 1.
DR   Pfam; PF00870; P53; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR602117-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR602117-1}.
FT   DOMAIN          44..227
FT                   /note="p53 DNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF00870"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         124
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
FT   BINDING         127
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
FT   BINDING         176
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
FT   BINDING         180
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602117-1"
SQ   SEQUENCE   351 AA;  39814 MW;  EB847588A9303056 CRC64;
     MQTRSTKANM KNASQTPPEN QQQQAQGRGS HPQVSDYNDQ LAEQTEQQQQ QQQNSDQWTS
     SSESVVTQKP FAQRNKCGMT LYSKSELMVP FVFSTSNSCE PNSMIRVHAE YTEERYANKP
     VERCPNHQYK DTLAATANIR QHFVRCEHVG AEYVEKDGGY FVRIPMCDST GFAFTCFSSC
     SGGINRRPLQ LVFTLEAPGT GKVLDICLIA LKVCANPLRD SSKEDDKMYA FDSSCDPFGD
     KKELAPLLHA LCVPNAKCTE EGAPNGPGLK GISTRRRAVR PEETMFKRGR GRFCDDSCFI
     FELHMNDFSK FRKFLWYMAN EDKIDQLISL DTPENPFREE DSMFSVETPF K
//