ID   A0A0N4WBV1_HAEPC        Unreviewed;       845 AA.
AC   A0A0N4WBV1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=SSD domain-containing protein {ECO:0000313|WBParaSite:HPLM_0000794501-mRNA-1};
GN   ORFNames=HPLM_LOCUS7937 {ECO:0000313|EMBL:VDO33379.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000794501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0000794501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO33379.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO33379.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; UZAF01016751; VDO33379.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4WBV1; -.
DR   WBParaSite; HPLM_0000794501-mRNA-1; HPLM_0000794501-mRNA-1; HPLM_0000794501.
DR   OMA; ERMGECM; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF192; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        202..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        334..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        632..650
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        657..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        683..701
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        722..744
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        750..778
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          205..362
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   845 AA;  95375 MW;  E34C8153F80AA64F CRC64;
     RQAIHEKWPL SYDNYVAGRA VTQNREVQVI ALARDDGNIL EHHYAEAVFR LDRYIQKRVR
     VLYKHRYYSY HDLCLQYKNS GCPANKHVHV LSDLYNHGFN ITFPYFRFGT EGGYLGGALG
     GVKLMKTENG TNILASAQAW FMIYHLKFFP TEMSYISGLW ENELGRHLAA YPEDPYIKIT
     YFHSQTLADE LRRNADSLLP RFVIAFILLV VFSMVCSIAL IDNTYYIDWS LSKPILAVLG
     VVNAGMGIVT SLGMLMLFGM PFSDIVSVMP FLVVAVGIDN MFLMIAAIRR TSRCLPVAER
     MGECMSDAAV AILITASTDA LSFGVGAITT LPAVHIFCVY TGVAIAFAFI YQITFFAALL
     VLFTKLEKNE RNTVSGLKTI ATWSQRIFNL GSRPDPVKGN DIKEAAIPGF FRDWYAPLLM
     NRVVRGIALM WYIIYLIFAY YGVTQIKEGL EPINLLVEDS YAIPHYKLLQ NYFWKYGATL
     QVVVNNAPDM RNSTSRQRIQ AMIGDFATTR HSIGMEAVQF WMTDMDIYYR DTLDMKIIDG
     AFYSMLRHWL ASKHNNVWAE DLYWGEDEDG NVTLKSFRFL LGMRDISSTT DQMDATLLFR
     EVAARWPEYN ITTFMPLWLF TDQYAIIIPN TVQNIIIALA CMVVIAFLLI PQPMCAFWVA
     LACGSIDFGV VGYMTLWGVN LDAISMITII MSIGFSVDYS AHITYGYVVS EALVPREKVR
     DALASLGWPL CQGALSTIIA VSVLADVPAY MIITFFKTVF LSISIGLLHG LVFLPVLLST
     FVRGCCFMDT NHKDAVEKMK FLSHEPQIVP YSSPSHVPIP LTEHSSAASI HNRSRASLKS
     PEHLE
//