ID A0A0N4WCD5_HAEPC Unreviewed; 480 AA.
AC A0A0N4WCD5;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Lig_chan-Glu_bd domain-containing protein {ECO:0000313|WBParaSite:HPLM_0000817201-mRNA-1};
GN ORFNames=HPLM_LOCUS8164 {ECO:0000313|EMBL:VDO34065.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000817201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0000817201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO34065.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO34065.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UZAF01016799; VDO34065.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4WCD5; -.
DR STRING; 6290.A0A0N4WCD5; -.
DR WBParaSite; HPLM_0000817201-mRNA-1; HPLM_0000817201-mRNA-1; HPLM_0000817201.
DR OMA; MIAKSAY; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF544; GLUTAMATE RECEPTOR 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 387..456
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 480 AA; 54569 MW; 7AB887A99166899D CRC64;
MTLISIDSGR GNEAMRGLAD TLEMPLISLT APLYPQDPPN FFEVSVRPSP AELLADFVIH
KEWREIILLT DGEHYKTPDT LLEQQLFNAH ISRPPLIHAF CEQLCLRSIQ TGVSLPWLWH
HLHRKSNAST KAQLLELPRD PAKFSDFLRN FNLRRSNHTN RILIDTTSSS RQQKFLAAVR
TAQFSQATYH YVIANFLINK ESRAYWNLKK HLKKLDDNFI NNYDDVDSRG ALAYDAMLVA
FSGFSKCLST NDSLFHGTFR HGRFFNRGYP GIYCDPLSDR THPSRPFASF EHGRTVTKAL
RGMSIDSKQG TLTGTIEFDR FGHRKNYDVA VIDLVSNTKA TFNSKEVLAW RQGAGFFADR
TVAQHTRKTM VNRYKNIVRV VTVWVAPFVM TKRECAQPNN RTECEGNNKY EGYCIDLLKL
LADRIEGFNF EVYLGEKTGS KLPDGSWDGM MGDLLTGKAD VAVASLTINQ VSHCDNLCIK
//
