ID A0A0N4WGI9_HAEPC Unreviewed; 627 AA.
AC A0A0N4WGI9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
GN ORFNames=HPLM_LOCUS9918 {ECO:0000313|EMBL:VDO38736.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0000992601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0000992601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO38736.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO38736.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UZAF01017172; VDO38736.1; -; Genomic_DNA.
DR STRING; 6290.A0A0N4WGI9; -.
DR WBParaSite; HPLM_0000992601-mRNA-1; HPLM_0000992601-mRNA-1; HPLM_0000992601.
DR OMA; RGVFMYF; -.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..627
FT /note="heparosan-N-sulfate-glucuronate 5-epimerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041041509"
FT DOMAIN 419..616
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
SQ SEQUENCE 627 AA; 70615 MW; 9E956F2D901921BF CRC64;
MIRWKSVKSS LLFGAICFML LLLDKSLVEY NEKQEKNPYL GNSYAPRKDS GSPANSCDPS
VIAELNRLKK AVNKAKCTAN NGKEMTCMRD ETEFYFPFSF IKKQYDVSGK MSKDGSRFEL
FTSYSKIRVP EGDSYDPVGP FGHFATYSVE TRDRVRCISA ESGVPMSTQW NATPYYYPIQ
IAQYGLQHYS RMLVNKTDED AIEKGLQSNE WKGSSDSQDS SERVFYHDAE KGNLVNITTS
GELSNAGCYV FLDQSPLHHV ISLEWLPIQN ASFSILVRII ETDILVLLNY VTHHDSRCVW
NDSVSFAGLE QVRSLFKIDI HVIPYILNYA QVSFSFSLGE LRNDWQSITR DALVDTSRAL
SSMNTSKKRE GNVVLHPGDI KLVSIGFRGA VVVRQKIVQA RNAHMKFFLT AADWLVSNQD
DEGGWSVPVE RAIAERRLVL DAGWHSAMAQ GHALSLLTRA HAVTKNASYL TAASNALDLF
EKDASAGGIR NKLFGYDWYE EYPTTPGSFV LNGFIYSLIG LYDFKSVKVN SEAPEKVHSG
VERASRMFST GMDSLRALLP LYDTGSGSIY DLRHVGLHTA PNLARWDYHA VHVYLLKWLV
QITGDKSLNE TADRWIAYSW GRKAKHN
//
