ID   A0A0N4WIU9_HAEPC        Unreviewed;       336 AA.
AC   A0A0N4WIU9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=adenosine deaminase {ECO:0000256|ARBA:ARBA00012784};
DE            EC=3.5.4.4 {ECO:0000256|ARBA:ARBA00012784};
GN   ORFNames=HPLM_LOCUS10897 {ECO:0000313|EMBL:VDO41453.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001090501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001090501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO41453.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO41453.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UZAF01017418; VDO41453.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4WIU9; -.
DR   STRING; 6290.A0A0N4WIU9; -.
DR   WBParaSite; HPLM_0001090501-mRNA-1; HPLM_0001090501-mRNA-1; HPLM_0001090501.
DR   OMA; NHFTIHA; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProt.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR   PANTHER; PTHR11409:SF43; ADENOSINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT   DOMAIN          12..330
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   336 AA;  37763 MW;  1387E948AD87A2C2 CRC64;
     MQFDVVKFSL QVELHLHLDG SIRFSTLLEL SLARGTPLKG AKTVEELKKV LITHEPANLS
     RVLEAFDLFL PIVRGDKAAI ERIAYEMCED QAANGVIYFE GRYSPHLLCL PGGELTAVGV
     VEAVKRGFDR GEAQFGVKAR SIICCIRATD CRHLGVVAID VAGCAHGADE QYEAKIVHIF
     QEAYKRGIHR TVHAGESGTA KEVYKAIHDM HADRIGHGYR VMRDPDMYRK YFVYDHRVHL
     EACPYSSVMT GAVPLDWKNH PIATWAKDKV NFSVSRDDPT CFDNTMLSEL ELVRSEIGLT
     PHQLWQCQLN AAHSCFLTEE EKRPLVEKIL AAEPHK
//