ID A0A0N4WK81_HAEPC Unreviewed; 1408 AA.
AC A0A0N4WK81;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Protein-tyrosine-phosphatase {ECO:0000313|WBParaSite:HPLM_0001147101-mRNA-1};
GN ORFNames=HPLM_LOCUS11463 {ECO:0000313|EMBL:VDO42936.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001147101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0001147101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO42936.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO42936.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; UZAF01017576; VDO42936.1; -; Genomic_DNA.
DR STRING; 6290.A0A0N4WK81; -.
DR WBParaSite; HPLM_0001147101-mRNA-1; HPLM_0001147101-mRNA-1; HPLM_0001147101.
DR OMA; EKNRQQC; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00047; PTPc; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF495; TYROSINE-PROTEIN PHOSPHATASE 69D; 1.
DR Pfam; PF00102; Y_phosphatase; 3.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1408
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035995665"
FT DOMAIN 155..266
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 775..1100
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1015..1091
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1147..1395
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1325..1391
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1408 AA; 159669 MW; D9C7480F928DDB62 CRC64;
MTTIFGLWTW WSTLILLLLR FTSGEEEAEP LNITSVTEET VSTTTPSGPA SADRLGVPRC
ESNYDCVHNG LCRKDADGYG RCLCPRSCPP YIPMDCMKQG SSSYYRLRQR YRHELPCGVM
DSSYKKKYDL PSPQCHQGRC SCPPMFDNWK TSDSPVLNLL PTKCDRRELA VLGIAYPSDA
VYKGTDVTLY CCVNMDPQGL IDVAGVLFVQ NTTVVREPTN HPFHHMTEFE KMNTPYCWEL
DIRNVQLSDS GSYMCHVNAN QQPSVNYTIE FQVKAPRTIQ NLTIVTNDVS ANVSWDVQQG
PQLKIGLRLV RRTGLNGQEV FSQTNAISPV TIGNLRAATP YKLYVTVNDS QTDPFEITEL
FNTAESKPHP PKYEDVRVLN SGSSLICEVE WRAPALTNGR ISRYYVRVQG AVRRMRPGGA
IVADDFPPPT DEEKCANWDQ REDASHGINP IEFTTEFLSC KYGPLKPNRN YTITVWAENS
AGRSSPLVFP KHCITNYAQP DVVEKPVTST NANHTSFNLA FKSKPDDTNG PISCYYIGIV
PLLRNVSLET LPPPQEIVMD TVSKAFSNNL NVLAAEKKRF FAYIAESYTD YPMDTVIGDG
RGVSGMKPCS VLYLSRYKAE DVVLRPGLKY TGFLIVRVDK DDRDENQGGA HYSRILDPMR
PRAYRQLHLS GPAYGFSGYF KPVFLEPEDE RSSIGAFFTV LVPLLAFLTM AAVMGLFVLH
KRGEVAQWCH WLWMSKESSL GAERTLLRPS TYHAIAVDDL PSEYLMRHRD SDFLFAQEYE
ALPHYKLDAV ASARKENACK NRYVNDLNEV RWSFFNSILQ FSCRYNDIRA FDATRVKLRV
INDDENSDYI NANMIRGWNG RKLFIAAQAP LDTTVADFWR MIWEQDSRLI VMVANLFEKN
RQQCTKYWPD DQPTRYGDLL ISPREASYFA DYAVRCFDVE PVNDRFNRMS PGAKSDLGSI
DSNPTSEYAN VPSVRHLNGH AETSFVGCGT ARRVVQYHFT NWNDYKAPEC STGLLRFLHR
LRALPEFEDY PVVIHCSYGC LSAGVGRTGT FIAIDSMLDQ CAAEGKVDIF DCVSALRKQR
NLMVQSQEQY VFIYKALAEW HLFGYTDMDV EQLIEHYQTL IDPGMRYDDC GITKLVARSD
AAPATGMEAE FRKLERSLET PAKCSFAAKE DNIMKNRFDS AVPYDRNRIV LRASIGYADT
TYINASSLKG YFYPYVLAQD PVSEHTVFDF WRMISELNVT TLVMLSNEED WSPSEKYWPS
ELHGTVVYER PPYNVSVQLT GEEHFPYYIA RRLSYRMKED TGTRNVMQFA FTAWPSSSVV
PASSEPLLSL VGRVLERQSG LPDSGPIVLH CRNGSSETGV YCCISLLLER LKAEQRVDVF
QTVKGLQNQR PLVFSKLVCF SVVCFCSR
//
