ID   A0A0N4WN07_HAEPC        Unreviewed;       410 AA.
AC   A0A0N4WN07;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=PKS_ER domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001263301-mRNA-1};
GN   ORFNames=HPLM_LOCUS12629 {ECO:0000313|EMBL:VDO46219.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001263301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001263301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO46219.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO46219.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAF01017924; VDO46219.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4WN07; -.
DR   STRING; 6290.A0A0N4WN07; -.
DR   WBParaSite; HPLM_0001263301-mRNA-1; HPLM_0001263301-mRNA-1; HPLM_0001263301.
DR   OMA; WVPGYDI; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR11695; ALCOHOL DEHYDROGENASE RELATED; 1.
DR   PANTHER; PTHR11695:SF294; RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT   DOMAIN          16..367
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   410 AA;  45140 MW;  9C253B690982C6DA CRC64;
     MRAWVARSPT DPMELKTLPS PVLTKPDQVL IKVKAASVNP VDPMMAKGYG MEILEVLKRL
     DAFDPSARRF PLTPGRDCAG IVEAIGPAVK GIKPGDEVMA VVPAVWAGSH AEYVISQEAC
     CSRKPSNLNF AEAAAMPYAA NTAWAALVCV ARMNPRSKPS LFLYNCYAVY GKDRQLIIAE
     RVLIHGGGGG VGTMAIQMLK AWGTDKVVAT CSEDSAITVR KLGAIPVDYR AKDARDQLIE
     EGPYEVVFDC ADSELARWSD NIMSAWKNSV HVSVASPLLR DTDRYGLLQG LITTAVKHFC
     RSYESALRGR WFSYAFFMPS QECMQQLTKF AEDGKIRPVV ERVQSFDKLP EAYEKVSALH
     GRGKTVLSWE AIRPVVERVQ PFDKLPEAYE KVSALHGRGK TVLSWEAVAN
//