ID   A0A0N4WNT7_HAEPC        Unreviewed;       639 AA.
AC   A0A0N4WNT7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=SLC12 domain-containing protein {ECO:0000313|WBParaSite:HPLM_0001297501-mRNA-1};
GN   ORFNames=HPLM_LOCUS12967 {ECO:0000313|EMBL:VDO47339.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001297501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001297501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO47339.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO47339.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; UZAF01018036; VDO47339.1; -; Genomic_DNA.
DR   STRING; 6290.A0A0N4WNT7; -.
DR   WBParaSite; HPLM_0001297501-mRNA-1; HPLM_0001297501-mRNA-1; HPLM_0001297501.
DR   OMA; YFKAADS; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 3.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        85..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        110..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          33..224
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          240..343
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          366..492
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          570..639
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          523..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..566
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   639 AA;  72108 MW;  1E7465368A55D048 CRC64;
     MVFGASVSEM FIRDKYGQSA MSKLTISEIA WPFPIVILFG CLGATIGAGM QSLTGAPRLL
     QAIAFDDVIP FLKPFRKMDS RGEPIRAIFI TILICWMGIL IAVIENITAL ITQFFLMCYL
     GVNTACALQS LLKSPGWRPS FRYFHWSLSM LGAFLCVAVM FISAWHFALV AIFIGAAVYK
     YIEYAGAEKE WGDGIRGLGL SAARFALLNV ENKPQHSRNW RPQLLVLLEN TDSPNTHGML
     SFVSQLKAGK GLTLVAMCRE GKFASDAEDA AAQQRNLDCL MKKYKIKGFG DILVTEHIME
     GVSCLVQTSG LGALRHNTVV ISWPEQWITE HSWDVGHRFV SALRACSAAK CAILVPKNVE
     RFPPSNTKVS GNLDVWWVVH DGGLLMLLPF LLRQHKTWKN AVIRLFAIAQ LEDNNVQMKS
     DLEKFLYHLR IEAEVFVIEM PDSDISDYTY ERTLKMEERT KLLRSLNKAD REKDLQTHIE
     EVVRERKLSK INEEEAVSTD SCTSPCKMQN AALEKTLEIV PEDNQDTESK KIEGKGVRFS
     DSNSVEENHK PGNGTLERDN EERRRRRRYN VHKMHTAVKL NELMREKSGD CQLLIVNLPG
     PPDQDSDIYY MEFIEALTES LNRVLLVRGT GAEVVTIYS
//