ID A0A0N4WRW9_HAEPC Unreviewed; 422 AA.
AC A0A0N4WRW9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=HPLM_LOCUS14245 {ECO:0000313|EMBL:VDO52257.1};
OS Haemonchus placei (Barber's pole worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001425301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HPLM_0001425301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO52257.1, ECO:0000313|Proteomes:UP000268014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHpl1 {ECO:0000313|EMBL:VDO52257.1,
RC ECO:0000313|Proteomes:UP000268014};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; UZAF01018498; VDO52257.1; -; Genomic_DNA.
DR STRING; 6290.A0A0N4WRW9; -.
DR WBParaSite; HPLM_0001425301-mRNA-1; HPLM_0001425301-mRNA-1; HPLM_0001425301.
DR OMA; NVSCRVW; -.
DR Proteomes; UP000038042; Unplaced.
DR Proteomes; UP000268014; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT DOMAIN 1..255
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 422 AA; 47323 MW; 5ECF6AB19D0DB24F CRC64;
MIDLTKSEVE KRYIAGALNG KCPANAQVIY GDTDSVMVKF GVKTVAEAME IGLDAATEVS
KIFTPPIKLE FEKVYFPYLL INKKRYAGLY FTKPDKHDKM DCKASLIFSG LETVRRDNCP
LVAKVLNTCL EKLLIARDAT SALEFAKRVI SDLLCNKIDI SLLIISKELT KSGDKYQAKQ
AHVELAARMR KRDPGSAPRL GDRVPYVIIA SAKNVPAYEK AEDPAFVLKN NIPIDTKHYL
TNQLAKPLAR IFEPILGDRA ERFVELRDDG FSMVVLDRDI IEECVVVAGA YECTLVEGEH
TRVRTMVQSK VGGLAAFTKK MVTCLGFVNL FEGLTSKFIT FFRCKAVLKD QTGAACDFCI
SKGKLPEIYV GRYLAFQEKM CRICTAITVD RGYWQCMSPA LWEEPRVIRY DVTQLKKTSA
LK
//