ID   A0A0N4WRW9_HAEPC        Unreviewed;       422 AA.
AC   A0A0N4WRW9;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=HPLM_LOCUS14245 {ECO:0000313|EMBL:VDO52257.1};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001425301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001425301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO52257.1, ECO:0000313|Proteomes:UP000268014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHpl1 {ECO:0000313|EMBL:VDO52257.1,
RC   ECO:0000313|Proteomes:UP000268014};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; UZAF01018498; VDO52257.1; -; Genomic_DNA.
DR   STRING; 6290.A0A0N4WRW9; -.
DR   WBParaSite; HPLM_0001425301-mRNA-1; HPLM_0001425301-mRNA-1; HPLM_0001425301.
DR   OMA; NVSCRVW; -.
DR   Proteomes; UP000038042; Unplaced.
DR   Proteomes; UP000268014; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000268014}.
FT   DOMAIN          1..255
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
SQ   SEQUENCE   422 AA;  47323 MW;  5ECF6AB19D0DB24F CRC64;
     MIDLTKSEVE KRYIAGALNG KCPANAQVIY GDTDSVMVKF GVKTVAEAME IGLDAATEVS
     KIFTPPIKLE FEKVYFPYLL INKKRYAGLY FTKPDKHDKM DCKASLIFSG LETVRRDNCP
     LVAKVLNTCL EKLLIARDAT SALEFAKRVI SDLLCNKIDI SLLIISKELT KSGDKYQAKQ
     AHVELAARMR KRDPGSAPRL GDRVPYVIIA SAKNVPAYEK AEDPAFVLKN NIPIDTKHYL
     TNQLAKPLAR IFEPILGDRA ERFVELRDDG FSMVVLDRDI IEECVVVAGA YECTLVEGEH
     TRVRTMVQSK VGGLAAFTKK MVTCLGFVNL FEGLTSKFIT FFRCKAVLKD QTGAACDFCI
     SKGKLPEIYV GRYLAFQEKM CRICTAITVD RGYWQCMSPA LWEEPRVIRY DVTQLKKTSA
     LK
//