ID   A0A0N4WXS6_HAEPC        Unreviewed;       348 AA.
AC   A0A0N4WXS6;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0001663601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0001663601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ECSIT family.
CC       {ECO:0000256|ARBA:ARBA00007674}.
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DR   AlphaFoldDB; A0A0N4WXS6; -.
DR   WBParaSite; HPLM_0001663601-mRNA-1; HPLM_0001663601-mRNA-1; HPLM_0001663601.
DR   OMA; EEDFSHW; -.
DR   Proteomes; UP000038042; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   InterPro; IPR046448; ECSIT_N.
DR   PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR   PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   Pfam; PF06239; ECSIT_N; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          216..337
FT                   /note="ECSIT C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01284"
SQ   SEQUENCE   348 AA;  40611 MW;  8588774E1BCF59A3 CRC64;
     LRVVSAAKAH EGSIIHVEER FQAVPPPKRN KESFMAAIAN FRESKPRGHV EFITTALKYL
     KEYGIHKDLE VYKALLNIFP KGKMIPQNTF QRIFLHFPMQ QNCCVKVLDE MEWHGVHPDK
     EIHDIVVNAF GEWNFATRKI KRMLYWMPKL RYSNKYLDRR IVEGKSLTAA ELAGVALKMM
     CPDPGTSISL TRVSGHTPTT PPTETEKDAW LAFAQSHIQK NLVRDLPEDT EVFIDGPHTV
     YVMEHQVQYI TMTCTPLYPP GDEFKHETFE EDFSHWFTEW KNERYERKTS VHEQKHETIL
     ALGAMHRNDN KTASLWLERL QEENPNLSRL RPRLRLDRGV EYSAEAQQ
//