ID   A0A0N4X6V7_HAEPC        Unreviewed;       292 AA.
AC   A0A0N4X6V7;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial {ECO:0000256|ARBA:ARBA00016714};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
DE   AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase {ECO:0000256|ARBA:ARBA00031181};
OS   Haemonchus placei (Barber's pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Haemonchus.
OX   NCBI_TaxID=6290 {ECO:0000313|Proteomes:UP000038042, ECO:0000313|WBParaSite:HPLM_0002009901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:HPLM_0002009901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline
CC       catabolite. Has high activity toward isobutyryl-CoA. Could be an
CC       isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also
CC       hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000256|ARBA:ARBA00024871}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005254}.
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DR   AlphaFoldDB; A0A0N4X6V7; -.
DR   WBParaSite; HPLM_0002009901-mRNA-1; HPLM_0002009901-mRNA-1; HPLM_0002009901.
DR   OMA; LVWEQIR; -.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000038042; Unplaced.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          20..274
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   292 AA;  32631 MW;  200811D766A43BCD CRC64;
     LNHNWIGYEA DLDQICYQGL STEYQLNHLI GNLSKTFVAL IDGIVMGGGC GLSVNGRYRV
     ATERTMLAMP ETALGLFPDV GGSYFLSRLK NNLGFYLALT GYRLHGADAL HAGLATHYIP
     SAKLADLQKK LLSLDNVTDK SVDATIREFE PANIPGFTLE EHLPVIERTF EATSVEGIVS
     NLKKENTEWA EKQLKTLSKM SPTSMKVTFK QLKNGANMDF SKVFTMEYRL TQRSVEDHDF
     HEGCRAILID KDRNPKWKPA TLEEVSDAHI EHYFAPLDGK EDLFLGDSNA KI
//