ID A0A0N4XC54_NIPBR Unreviewed; 451 AA.
AC A0A0N4XC54;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=BOS complex subunit NCLN {ECO:0000256|ARBA:ARBA00034873};
DE AltName: Full=Nicalin {ECO:0000256|ARBA:ARBA00041615};
GN ORFNames=NBR_LOCUS10 {ECO:0000313|EMBL:VDL61780.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000000901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000000901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL61780.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; UYSL01000002; VDL61780.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4XC54; -.
DR STRING; 27835.A0A0N4XC54; -.
DR WBParaSite; NBR_0000000901-mRNA-1; NBR_0000000901-mRNA-1; NBR_0000000901.
DR OMA; GGCITAY; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR016574; Nicalin.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR31826; NICALIN; 1.
DR PANTHER; PTHR31826:SF0; NICALIN; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 173..382
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 451 AA; 49812 MW; B1EB3EFEC1BD7B7A CRC64;
MEELLEAIRN PFFIVYISVL LTFCVVSGSQ QLGDKVELEF QAFRLQQYEL NGNTLGSKNF
RVQYEAVSLN SKALRRCVVT SWRDLAQHNL DELLANSLFM ELERKLAMAR TDLAVYVSYS
CPEASAILSD VVSSSITSKS ATQQLISSIA ANTFQFTSTG SPASTPLTYK PNNIIGRLSS
SERSAPTIAF VAHYDSHAAF PGAAVGADSN GSGVVVLLEL LAIFRKLYDK ASTRPPFNLV
FVWTAAGKYN YQGARQFIED FQSDNSEDNR LELAICVEAL GTAGPMRMHA SKQPADGSAA
DRLLRRLRLA APNQSVELVT KKISINQPSA WEHEKFNIKR LPAITLSRLP SHDSLIRKSM
MDTPSRLSLD ALEKNIRTIA EAVLGHMLSL PEGGYSKDSR ISADTSVLSR DAVDRQRLAH
AVRLFASRPR PAVSRSQRLL EGAMLKLRKR V
//
