ID A0A0N4XIV9_NIPBR Unreviewed; 314 AA.
AC A0A0N4XIV9;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Disks large 1 tumor suppressor protein (inferred by orthology to a D. melanogaster protein) {ECO:0000313|WBParaSite:NBR_0000246101-mRNA-1};
GN ORFNames=NBR_LOCUS2462 {ECO:0000313|EMBL:VDL66051.1};
OS Nippostrongylus brasiliensis (Rat hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000246101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:NBR_0000246101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL66051.1, ECO:0000313|Proteomes:UP000271162}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYSL01002823; VDL66051.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N4XIV9; -.
DR STRING; 27835.A0A0N4XIV9; -.
DR WBParaSite; NBR_0000246101-mRNA-1; NBR_0000246101-mRNA-1; NBR_0000246101.
DR OMA; ENMAQEN; -.
DR Proteomes; UP000038043; Unplaced.
DR Proteomes; UP000271162; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd11861; SH3_DLG-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF72; DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 288..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 129..314
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 78..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 314 AA; 36325 MW; AEE89BF2603FD590 CRC64;
MYTFRALFDY DHTREVGVPH RSISFQYGDV LHVMNTSDDD WWTAKKVMEN GEESPEGVIP
SKKRIEKREK ARRKQVNFNA GSMSLGRSSG TGMDGRRGSK SQLSFSRKFP FVKSTDRLNE
FTDQELNYVR PVIILGALKD RINDELVTRN PDRFSSCVPH TSRPPREHEV DGRDYHFVSK
AQMEHDVKNN LFIEAGQFQN NLYGTSIDSV RAVAQQGRHC ILDVSGNAIR RLQSVANIHP
IAIFVKPSSH HHIMQLDNTM NEEEALQQYA RCQRLEQTFG DLFTRTCFYF YFFNAFVIYD
PTVLFLITRE GLVR
//
