ID   A0A0N4XTD1_NIPBR        Unreviewed;       464 AA.
AC   A0A0N4XTD1;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN   ORFNames=NBR_LOCUS5849 {ECO:0000313|EMBL:VDL69438.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000584801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000584801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL69438.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC       {ECO:0000256|RuleBase:RU365065}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC   -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC       subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC       ECO:0000256|RuleBase:RU365065}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR   EMBL; UYSL01019761; VDL69438.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4XTD1; -.
DR   STRING; 27835.A0A0N4XTD1; -.
DR   WBParaSite; NBR_0000584801-mRNA-1; NBR_0000584801-mRNA-1; NBR_0000584801.
DR   OMA; ASCVIFY; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR009716; Ferroportin-1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR   PANTHER; PTHR11660:SF69; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR   Pfam; PF06963; FPN1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|RuleBase:RU365065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365065};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT   TRANSMEM        80..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        111..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        167..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        257..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
FT   TRANSMEM        417..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365065"
SQ   SEQUENCE   464 AA;  50792 MW;  DBE55D5934C04C9D CRC64;
     MPFDGERCAP ERPTSKLLLF AAFLSTCMED RAWSFCVSLC MQALGGMRMV SIEQFAEGIG
     QMVLSGHLGR AFDRVSRKTA IMSVIPVNNI SIVLAASMFI VCLTVDPNSP WYFVFLVLGI
     LVCAVNRLFL NAEKFLVSRD WVVVISNGET LSSLNATLTA LDQLTNVISP IITGLLVTAW
     GLRVTCAIFG SFSLVSMASK AFFLRALYIR TPQLAQKQQE QKEKENDKKV RKSILEKIAA
     AFESIPDVLR TYTRQTVIAA AFGMSLLFMT VMGFDGLAVG YGQSAGLPDY VLGAFRSFGS
     AMGILGALSY AFFERRLGVR KTGLLGLTWS TAEGNAAHQN QVIGNGQSLD SIITFLSGIA
     SARFGLWMAD LSIIHIMQEG VPESDRNTVF GVHNALCQTF SVLKDVLVII LPDPSTFGIC
     ILISYVFVTS GYFSFVYYLV KHPVATSNSH KCSRANDELN ETRL
//