ID   A0A0N4XU59_NIPBR        Unreviewed;      1058 AA.
AC   A0A0N4XU59;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Exportin-1 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:NBR_0000622201-mRNA-1};
GN   ORFNames=NBR_LOCUS6223 {ECO:0000313|EMBL:VDL69812.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000622201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000622201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL69812.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the exportin family.
CC       {ECO:0000256|ARBA:ARBA00009466}.
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DR   EMBL; UYSL01019786; VDL69812.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N4XU59; -.
DR   STRING; 27835.A0A0N4XU59; -.
DR   WBParaSite; NBR_0000622201-mRNA-1; NBR_0000622201-mRNA-1; NBR_0000622201.
DR   OMA; WAFKHNN; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR041123; CRM1_repeat.
DR   InterPro; IPR041235; Exp1_repeat_2.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR045065; XPO1/5.
DR   InterPro; IPR014877; XPO1_C_dom.
DR   InterPro; IPR040485; XPO1_repeat_3.
DR   PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR   PANTHER; PTHR11223:SF2; EXPORTIN-1; 1.
DR   Pfam; PF08767; CRM1_C; 1.
DR   Pfam; PF18777; CRM1_repeat; 1.
DR   Pfam; PF18784; CRM1_repeat_2; 1.
DR   Pfam; PF18787; CRM1_repeat_3; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM01102; CRM1_C; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          19..85
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
SQ   SEQUENCE   1058 AA;  120563 MW;  2808E6766A797C0B CRC64;
     MLQVVTMMNR ATGEEQKLAN MILVELKENP NSWTKVDAIL EYSDLAESKY FALQILESVI
     QTKWKSLPLV QRDGIKGFIV QFILKLSESR IESEKNSLLL HKLNLVLVQI VKQDWPKHWP
     SFITDIVESS KTNDNICVNN MNILSLLSEE VFDFGNQNLT QAKEQHLKQQ FCGQFQEVFT
     LCITILEKCP ANSIVEATLK TLHRFLSWIP VGYVFETNIT QLLSENFLSL EVYRVVTLQC
     LTEISMIQID AEDNAYKEKL CAMFCATIKE IGSLLGEGAD LATAYQKGTD QDQKFISCLA
     QFLVAFLKDH SALVENATPA CPQVTDYHRY AVELLLSISQ VEDVEIFKVC LDYWCALTSE
     LYRLNPFTPP SPPIAISFSC GGAAGGKEHP RRKLYKEHLS NLRTIMISRM AKPEEVLVVE
     NDQGEVVREI VKDTDSITLY KNMRECLVYL THLDCKDTEQ KMTDKLASQV NGSEFSWKNL
     NTLCWAVGSI SGTMVEEDEK RFLVLVIRDL LGLCEQKRGK DNKAVIASNI MYVVGQYPRF
     LRAHWKFLKT VINKLFEFMH ETHEGVQDMA CDTFIKIAMK CKRHFVIMQV GEQTPFIEEM
     LKNLSGIICD LAPSQVHVFY EAVGHIISSA SDEPDQQADL IEKLMSLPNS VWDEIIANAG
     ENMSVLEDQE VSKNLLNILK TNVACCKAAG NPFITQLSRL YIDLLSLYRI LSEKVSTAVE
     QNGQEVLKMP LLKTMRAVKR EILILISTWV ASAKDRQMVL ENIVPPLFDA VLFDYQKNVP
     AAREPKVLSL LSIIVTKLGS MLSSQVPQIL AAVFECTLEM INKDMEAFPE HRTNFFQLIH
     SLTTECFQVF LALPPEQLSY IIDAVVWAFQ HSMRNVAEIG LDILKDMLDR VEFLPRDQSQ
     PFYKRFYMQI LQHVLAVVAD SSQVHVAGLT YYAEVLCRLF KACEFLITVP LNDENPKQSN
     VDYIYEYIAN IFVQHFTNLT EGQIRVIIKG FFSFNTDQGG MRNHLRDFLV QIKEFNGEDT
     SDLFLEEREA EIQAVQAKKN AVPGMLDPNA MVEEEEMR
//