ID   A0A0N4XVY3_NIPBR        Unreviewed;       487 AA.
AC   A0A0N4XVY3;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Amiloride-sensitive sodium channel {ECO:0000313|WBParaSite:NBR_0000699501-mRNA-1};
GN   ORFNames=NBR_LOCUS6996 {ECO:0000313|EMBL:VDL70585.1};
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Heligmosomidae; Nippostrongylus.
OX   NCBI_TaxID=27835 {ECO:0000313|Proteomes:UP000038043, ECO:0000313|WBParaSite:NBR_0000699501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:NBR_0000699501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL70585.1, ECO:0000313|Proteomes:UP000271162}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   EMBL; UYSL01019848; VDL70585.1; -; Genomic_DNA.
DR   STRING; 27835.A0A0N4XVY3; -.
DR   WBParaSite; NBR_0000699501-mRNA-1; NBR_0000699501-mRNA-1; NBR_0000699501.
DR   OMA; TQDYVSR; -.
DR   Proteomes; UP000038043; Unplaced.
DR   Proteomes; UP000271162; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001873; ENaC.
DR   Pfam; PF00858; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271162};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        7..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   487 AA;  55642 MW;  07BB285E4E564683 CRC64;
     MAIKTACNVI IMLFLIGVCV VLFVLQSIYF INRSTGNSQK ELTDTVDGEP LSMPALVICN
     RMPFSQDGVN SVNSALRQEQ AMRYLLEWTN PSLREDADYV AMSRTYMDQG QTTVFQYIPQ
     NIRNQSINQM QYMCQSMVNS CSYQGVVIQA YDCCRSILYK VPTTKGLCWA FYDRSLMQNS
     TSSAKQFTMT FQMSRNSWYS ERTVPVHPGI DIYLRENLDD VASLSNQLET PIRLLNKKGV
     RLRMRKEVRA DVRRSHCGQT VGSAESVDRN ALEKNETNLL MCTIMVSMSY CNCHPLIAEM
     MPYDSNRFRD FSLRVNTTQV CTVDQYEMCA RRYIDLTRPS AWREPIPRDM PGVADIERCR
     SENPYPCTVA LYPGTLDQYD LPSDYQTTQD FVARLVLEYS TTRTTEVLIT SDPTLYELLS
     YIGYNLATWF CIGHIIWSLY ALIRDHICCC CSNKVTPVSP RRAFSISHPV ETQSEAKDSA
     EDGESAS
//